Main Article Content

Abstract

Portulaca oleracea L. is one of the plants empirically used as medicine and contains flavonoid compounds assumed to have an immunomodulatory effect. The research aimed to determine the immunomodulatory effect of ethanol extract of Portulaca oleracea L  by Delayed Type Hypersensitivity parameter. The research used 20 male rats (Rattus norvegicus) divided into 5 groups where each group consisted of 4. Group I as a normal group (without treatment), group II (NaCMC control), group III, IV and V (treatment groups) were given EEHK with doses of 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW doses. The dosage form was orally given for 7 days. On day 3, the rats were induced with SDMD antigen 10% v/v by intraperitonial and intraplantar on day 7. The observations were conducted by measuring the volume change of the rat's feet at the 4th, 24th, and 48th hours using a pletismometer. The research data obtained were statistically processed using Paired Samples T Test, One-Way Anova and Post Hoc LSD tests. The results of the research showed that the ethanol extract of common purslane was effective as an immunomodulator.

Keywords

Portulaca oleracea L. Immunomodulators Delayed Type Hypersensitivity (DTH)

Article Details

How to Cite
Putra, B., Azizah, R. N., & Nopriyanti, E. M. (2020). Efek Imunomodulator Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) terhadap Tikus Putih (Rattus norvegicus) Jantan dengan Parameter Delayed Type Hypersensitivity (DTH): Effect of Immunomodulator of Purslane Herb Ethanol (Portulaca oleracea L.) on Rat (Rattus norvegicus) with Delayed Type Hypersensitivity (DTH) Parameter. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 6(1), 20 - 25. https://doi.org/10.22487/j24428744.2020.v6.i1.14106

References

  1. Andayani, D, Suprihartini, E & Astuti, M. (2018). Efek Antiinflamasi Ekstrak Etanol Krokot (Portulaca oleracea L.) pada Udema Tikus yang di Induksi Karagenin. Journal of Pharmaceutical Science and Clinical Research. 3(1):43-49. Antari, A, L. (2017). Imunologi Dasar. Yogyakarta: Deepublish. Bellanti, A.J.(1989) Imunologi III Yogyakarta: Gajah Mada University Press. Devagaran, T & Diantini, A. (2012). Senyawa Imunomodulator Dari Tanaman. Bandung : Student e-Journal. Effendi, N & Widiastuti, H. (2014). Identifikasi Aktivitas Imunoglobulin M (IgM) Ekstrak Etanolik Daun Ceplukan (Physalis Minima Linn.) pada Mencit. Jurnal Kesehatan. 7(2):353-360. Emelda, A, Rahman, S, & Hardianti. (2015). Efek Imunostimulan Infus Buah Mahkota Dewa (Phaleria Macrocarpa (Scheff.) Boerl.) Asal Kab. Sidrab Sulawesi Selatan Terhadap Sekresi Antibodi Tikus Putih (Rattus Norvegicus) Jantan Dengan Teknik Hemaglutinasi (Skripsi). Makassar: Fakultas Farmasi Universitas Muslim Indonesia. Faradilla, M. (2013). Efek Imunomodulator Polisakarida Rimpang Temu Putih (Curcuma zedoaria(Chrtetm.) Roscoe). Jurnal Ilmu Kefarmasian Indonesia. 12:273-278 Kusmardi, Shirly, K, & Enif, E.T. (2007). Efek Imunomodulator Ekstrak Daun Ketepeng Cina (Cassia alata. L) Terhadap Aktivitas dan Kapasitas Fagositosis Makrofag. Makara Kesehatan. 11(2):50-53. Mi Park, Young, Young Lee, Hak, Gyu Kang, Yang, Hoon Park, Sang, Gun Lee, Bong, Ju Park, Yeon, Geun Oh, Hong, In Moon, Dae, Pill Kim, Young, Seon Park, Deuk, Man Lee, Hyang, Jin Kim, Ok, Jeong Yang, Hyeong, Jung Kim, Min, & Rae Lee, Young. (2019). Immune-enhancing effects of Portulaca oleracea L-based complex extract in cyclophosphamide-induced splenocytes and immunosuppressed rats. Food and Agricultural Immunology, Taylor & Francis Group.30(1):22. Patroni, R., & Yuniarti, Afrizal. (2003). Pengaruh pemberian ekstrak etanol umbi bidara upas (Merremia mammosa) terhadap fagositosis makrofag dan produksi NO makrofag studi eksperimental Infeksi Salmonella Typhimurium pada mencit Balb/C. Semarang:Universitas Diponegoro. Praworo, Kukuh. (2011). Terapi Medipic, Medical Picture. Jakarta: Penebar Plus. Sri Harti, A. (2013). Imunologi Dasar & Imunologi Klinis. Yogyakarta:Graha Ilmu. Wati, A, Herman, H & Sari, D.P. (2013). Uji Hepatoterapi Ekstrak Etanol Buah Merah (Pandanus conoideus Lam.) Asal Kabupaten Jayawijaya Papua Dengan Parameter SGPT Terhadap Tikus Putih Jantan. Jurnal Bionature.(14)2:100-104. Zhou, Y, Xin, H, Rahman, K, Wang, S, Peng, C, & Zhang, H. (2015). Poleracea L.: A Review of Phytochemistry and Pharmacological Effects. Biomed Res Int. 2015;2015:925631.