Article Sidebar

Submitted
Feb 11, 2020
Accepted
Sep 17, 2020
Published
Sep 30, 2020
Download
PDF
Statistic
Read Counter : 2701 Download : 3956

Main Article Content

Abstract

Burns often occur in various daily activities, second-degree burns are the most common. Snakehead oil (Channa striata) contains fatty acids such as omega-3 and omega-6 which can accelerate the wound healing process. This study aims to determine the physical stability and effectiveness of emulgel preparations containing snakehead oil for 8 weeks of storage of the wound healing process, which was given topically to 5 groups of treated mice.Second degree burns were made on the skin of mice, then the wound was smeared with emulgel preparations and the healing process was observed for 21 days. Cork fish oil was formulated in several concentrations; F1 (5%), F2 (10%) and F3 (15%). Organoleptic datas showed that all formulas formed as semisolid dosage form with a pale yellow color and distinctive smell of snakehead oil. The emulgel has homogenous state, not irritating effect and pH range of 5,7 to 5,3. The dosage which has a concentration of 15% gives the smallest spread but has the longest adhesion. In the Freeze and Thaw stability test conducted at 40C and 400C the dosage remains stable with an increase in globule size. Data analysis of the effectiveness of burn healing was done by two-way ANOVA statistical tests and continued with the Tukey test. The independent variable is the treatment group and the recovery time of mice while the dependent variable is the diameter of the burn. Statistical results showed that all formulas differed significantly (p <0.05) against negative controls indicating that they had effectiveness in wound healing. F3 has a better effectiveness of healing burns on the 15th day with 100% healing percent compared with F1 and F2 on the 21th day.

Keywords

Emulgel Luka Bakar Minyak Ikan Gabus Penyembuhan Luka Bakar

Article Details

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

How to Cite
Nofriyanti, Sinata, N., & Mistawati, A. (2020). Formulasi Dan Uji Aktivitas Emulgel Minyak Ikan Gabus (Channa striata) Sebagai Penyembuh Luka Bakar : Formulation and Activity Test of Snakehead (Channa striata) Oil as A Burns Healing. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 6(2). https://doi.org/10.22487/j24428744.2020.v6.i2.15013

References

  1. Allen, L. V. 2002. The Art, Science and Technology of Pharmaceutical Compounding, Second Edition. American Pharmaceutical Association. Washington D.C.
  2. Anonim. 1995. Farmakope Indonesia Edisi IV. Departemen Kesehatan Republik Indonesia : Jakarta.
  3. Anonim. 2014. Farmakope Indonesia Edisi V. Departemen Kesehatan Republik Indonesia : Jakarta.
  4. Asmillyas. Handayani, F. Afriani, T dan Suardi, M. 2017. Formulasi Gel Minyak Ylang-Ylang dan Uji Daya Antibakteri Terhadap Bakteri Penyebab Jerawat. Jurnal Ipteks Terapan, 11(13): 246-25.
  5. Collins, N., and Sulewski, C. 2011. Ostomy Wound Management. 10-13
  6. Garg, A. Aggarwal, S. Garg and A. K. Sigla. 2002. Spreading of Semisolid Formulation: An Update. Pharmaceutical Tecnology : 84-102.
  7. Gusdi, O. (2012). Formulasi sediaan gel ekstrak ikan gabus (Channa striata) sebagai obat luka sayat. Skripsi. Program Studi Farmasi, Fakultas Kedokteran, Universitas Tanjungpura Pontianak
  8. Jawetz, E. Melnick JL dan Adelberg EA. 2012. Mikrobiologi Kedokteran edisi 25. EGC Penerbit Buku Kedokteran : Jakarta.
  9. Kumar. V. Cotran. 2007. Buku Ajar Patologi Anatomi. EGC 7(2): 367-378 : Jakarta.
  10. Lachman, L. Lieberman, H. A and Kanig, J. L. 1994. Teori dan Praktek Farmasi Industri, edisi III. Universitas Indonesia Press : Jakarta.
  11. Manan, A. 2007. Pharmacognosy and Pharmacology of Haruan (Channa striatus) a medicinal fish with wound healing properties. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 6(3): 52-60.
  12. Moenadjat, Y. 2003. Luka Bakar Pengetahuan Klinik Praktis Edisi II. Fakultas Kedokteran UI : Jakarta.
  13. Nagori, B. D dan Solanki, R. 2011. Role Of Medicinal Plants In Wound Healing. Research Journal Of Medicinal Plants. 5(4): 392-405.
  14. Pusponegoro A.D. 2005. Buku Ajar Ilmu Bedah Edisi ke-2. Penerbit Buku Kedokteran EGC 66-88 : Jakarta.
  15. Sabale, P. Bhimani, B. Prajapati, C. Sabale, V. 2012. An Overview of Medicinal Plants as Wound Healers. Journal Application Pharmaceutical Science. 2(11): 143-150.
  16. Sinambela, H.Y. (2012). Optimasi Formulasi Sediaan Salep Minyak Ikan Gabus (Channa striata Bloch) Sebagai Obat Luka Sayat dengan Metode Simplex Lattice Design. Skripsi. Program Studi Farmasi, Fakultas Kedokteran Universitas Tanjungpura Pontianak.
  17. Singla, V. Saini, S. Joshi, B. dan Rana, A.C. 2012. Emugel: A New Platform For Topical Drug Delivery. International Journal of Pharma and Bio Science. 3(2): 485-497.
  18. Sinko, Patrick J. (2006). Martin Farmasi Fisika dan Ilmu Farmasetika, Edisi 5, Penerbit Buku Kedokteran, Jakarta.
  19. Sumoza, N. S. Efrizal dan Rahayu, R. 2014. Pengaruh Gambir (Uncaria gambir R.) Terhadap Penyembuhan Luka Bakar pada Mencit Putih (Mus musculus L.) Jantan. Jurnal Biologi Universitas Andalas. 3(4): 14-19.
  20. Tranggono, R.I. dan Latifah, F. 2007. Buku Pegangan Ilmu Pengetahuan Kosmetik. Gramedia Pustaka Utama: Jakarta.
  21. Tri, NY. Effionora, A. Fadlina, CS. 2016. Formulasi Emulgel yang Mengandung Ekstrak Etanol Daun Binahong (Anredera cordifolia(Ten.) Steenis) dan Uji Aktivitasnya terhadap Propionibacterium acnes secara In Vitro. Jurnal Kefarmasian Indonesia. 6(2): 89-97.
  22. Voigt. 1994. Buku Ajar Teknologi Farmasi. Diterjemahkan oleh Soendani Noeroto S. Yogyakarta: UGM Press.
  23. Yanti, R. 2012. Pengaruh Nutrisi Ikan Gabus Terhadap Penambahan Berat Badan Balita Gizi Kurang. Skripsi. Riau: Universitas Muhammadiyah Riau.