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Sep 4, 2020
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Sep 10, 2021
Published
Oct 4, 2021
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Abstract

Background: Moringa oleifera L. leaves have analgesic activity due to their flavonoids content. These polar antioxidants compounds usually have difficulty to diffuse through the skin. Objectives: The purpose of this study was to evaluate the diffusion parameters of cream contains the lyophilized of M. oleifera leaves ethanol extract. Material and Methods: The lyophilized of M.oleifera leaves ethanol extract (5%) formulated as an o/w cream with 2% of cetyl alcohol as a stiffening agent. The physical characteristics of the cream were determined for organoleptic, homogeneity, pH, viscosity, spreadability, and type of emulsion parameters. The diffusion parameters were determined with Franz cell diffusion using the skin's snake as a membrane with 0; 10; 30; 60 and 90 minutes sampling time. Results: Physical characteristics of the cream showed that o/w as the cream type with pH, viscosity, and spreadability value were 4.72±0.03; 14.000±225 cps; and 5.7±0.20 cm, respectively. The diffusion parameter showed total flavonoids penetrate through the membrane was 360.134±0.20 µg/cm2 with flux 239,875 µg/cm2hr. Conclusions: This study showed a cream formulation that fulfills the required physical characteristics standard and can deliver active compounds to penetrate through the membrane.

Keywords

Moringa leaf Moringa oleifera L. Diffusion The Skin of the snake Penetration

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Author Biographies

Amriani Sapra, Sekolah Tinggi Ilmu Farmasi, Makassar

Department of Pharmaceutical Technology, Sekolah Tinggi Ilmu Farmasi, Makassar, Indonesia.

Suwahyuni Mus, Sekolah Tinggi Ilmu Farmasi, Makassar

Department of Pharmacology, Sekolah Tinggi Ilmu Farmasi, Makassar, Indonesia.

Dwirandy Dwirandy, Sekolah Tinggi Ilmu Farmasi, Makassar

Bachelor Students, Sekolah Tinggi Ilmu Farmasi, Makassar, Indonesia.

Rifka Malluka, Sekolah Tinggi Ilmu Farmasi, Makassar

Bachelor Students, Sekolah Tinggi Ilmu Farmasi, Makassar, Indonesia.

Nur Khairi, Sekolah Tinggi Ilmu Farmasi, Makassar

Department of Pharmaceutical Technology, Sekolah Tinggi Ilmu Farmasi, Makassar, Indonesia.

How to Cite
Sapra, A., Mus, S., Dwirandy, D., Malluka, R., & Khairi, N. (2021). Diffusion Study of Cream Formula of Lyophilized Ethanol Extract of Moringa oleifera L. Leaves : Studi Difusi Formula Krim Ekstrak Etanol Terliofilisasi Daun Kelor (Moringa oleifera L.). Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 7(2), 131-142. https://doi.org/10.22487/j24428744.2021.v7.i2.15275

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