Review of Impact and Handling of Potential Antihypertensive Drug Interactions in Chronic Kidney Disease Patients

Review Dampak dan Penanganan Potensi Interaksi Obat Golongan Antihipertensi pada Pasien Penyakit Ginjal Kronis

Abstract

Drug interaction is a type of Drug-Related Problems (DRPs) that can
eventually increase morbidity and mortality rates. CKD patients have a
significant risk of developing polypharmacy due to comorbid diseases and
pharmacokinetics' alteration. The literature review was conducted by
exploring all of the articles related to the drug interaction using drug
interaction analysis program in CKD patients, which obtained from three
databases, namely Google Scholar, PubMed, and Science Direct, using
several keywords combination. Based on the comprehensive reviews
conducted, it is known that the most common effects of antihypertensive
drug interactions in CKD patients are decreasing effects of antihypertensive
drugs, hypotension, and hyperkalemia. Handling management used for the
emergence of potential drug interactions is based on the severity of the drug
interactions and complete knowledge of the patients' clinical condition. The
management of drug interaction by monitoring blood pressure, diuresis, and
potassium levels; Monitor the related effect symptoms; Monitor the fluid
and body weight; Monitor the kidney and heart function. On the condition
where the handling management of potential drug interactions is not carried
out, elevated morbidity and mortality rates are the risks of complications
arising from the drug interactions.