Main Article Content

Abstract

Background: Diabetes mellitus is a heterogeneous group of diseases in the form of disorders in the body's metabolism clinically. Peperomia pellucida herbs have phytochemical containing which is antidiabetic potential development. Objectives: This study was conducted to compare the antidiabetic activity of ethanol extract and n-hexane fraction of Peperomia pellucida. Material and Methods: This research was conducted by make diabetic mice with 50 mg/kg.bw of streptozotocin induction, which was then treated with ethanol extract and n-hexane fraction of Peperomia pellucida with doses 250 mg/kgbw for 7 days.  Results: The results showed that the ethanol extract and n-hexane fraction of Peperomia pellucida reduced blood glucose levels in diabetic mice due to streptozotocin induction. The n-hexane fraction of Peperomia pellucida can lower blood glucose levels as much 244.00 ± 18.99 mg/dL better than the ethanol extract, which is 99.50 ± 28.17 mg/dL. Conclusions: Peperomia pellucida herb has the potential to be developed as an antidiabetic agent.

Keywords

Antidiabetic Peperomia Pellucida Ethanol Extract n-hexane Fraction

Article Details

Author Biography

Sholihatil Hidayati, STIKES dr. Soebandi, Jember, Indonesia

Program Studi Farmasi, STIKES dr. Soebandi, Jember, Indonesia

How to Cite
Hidayati, S. (2021). Antidiabetic Activity of Peperomia pellucida In Streptozotocin-Induced Diabetic Mice. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 7(2), 120-130. https://doi.org/10.22487/j24428744.2021.v7.i2.15429

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