Main Article Content


Background: Diabetes mellitus is a heterogeneous group of diseases in the form of disorders in the body's metabolism clinically. Peperomia pellucida herbs have phytochemical containing which is antidiabetic potential development. Objectives: This study was conducted to compare the antidiabetic activity of ethanol extract and n-hexane fraction of Peperomia pellucida. Material and Methods: This research was conducted by make diabetic mice with 50 mg/ of streptozotocin induction, which was then treated with ethanol extract and n-hexane fraction of Peperomia pellucida with doses 250 mg/kgbw for 7 days.  Results: The results showed that the ethanol extract and n-hexane fraction of Peperomia pellucida reduced blood glucose levels in diabetic mice due to streptozotocin induction. The n-hexane fraction of Peperomia pellucida can lower blood glucose levels as much 244.00 ± 18.99 mg/dL better than the ethanol extract, which is 99.50 ± 28.17 mg/dL. Conclusions: Peperomia pellucida herb has the potential to be developed as an antidiabetic agent.


Antidiabetic Peperomia Pellucida Ethanol Extract n-hexane Fraction

Article Details

Author Biography

Sholihatil Hidayati, STIKES dr. Soebandi, Jember, Indonesia

Program Studi Farmasi, STIKES dr. Soebandi, Jember, Indonesia

How to Cite
Hidayati, S. (2021). Antidiabetic Activity of Peperomia pellucida In Streptozotocin-Induced Diabetic Mice. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 7(2), 120-130.


  1. Aba, P. E., Asuzu, I. U. (2018). Mechanisms of actions of some bioactive anti-diabetic principles from phytochemicals of medicinal plants: A review. IJNPR. 9(2):85-96
  2. Dianaly ,T. A., Dudley, K. S., Selen, C. M. (2017). The Ldl Receptor-Related Protein 1: At The Crossroads Of Lipoprotein Metabolism And Insulin Signaling. J Diabetes Res. 2017: 8356537.
  3. Dipiro, R. L., Talbet, G. C., Yee, G. R., Maztake, B. G., Weels, L. M. (2016). Pharmacotheraphy, a Patophysiologic Approach, Ed. 9th, New York: Mc Graw-Hill Co. pp 1333-1367
  4. Hajiaghaalipour, F., Khalilpourshbafi, M., Arya, A. (2015). Modulation of Glucose Transporter Protein by Dietary Flavonoids in Type 2 Diabetes Mellitus. Int J Biol Sci. 11(5): 508-524
  5. International Diabetes Federation. (2017). IDF Diabetes Atlas 7 Edition. Brussels: International Diabetes Federation. {Diakses: 16 September 2020}
  6. Kharbanda, C., Alam, M. S., Hinna Hamid, H., Javed, K., Bano, S., Ali, Y., Dhulap, A., Pasha, M. (2016). Novel Piperine Derivatives with Antidiabetic Effect as PPAR-γ Agonists. Chem Biol Drug Des. 88(3):354-62.
  7. Kinho, Julianus, Arini, Diah, I. D., Tabba, Supratman, Kamma, Harwiyaddin, Kafiar, Yermias, Shabri, S., Karundeng, Mood C. (2011). Tumbuhan Obat Tradisional di Sulawesi Utara Jilid 1. Manado: Balai Penelitian Kehutanan Manado. ISBN: 978-602-98144-1-5.
  8. Lim, A. H. (2014). Diabetic nephropathy – complications and treatment. Int J Nephrol Renovasc Dis. 7: 361–381.
  9. Mathew, M. and Harindran, J. (2018). Antioxidant And Free Radical Scavenging Activity Of Peperomia Pellucida (L.) Kunth: An In Vitro Study. WJPR. 7(17):2018.
  10. Mgbeahuruike, E. E., Fyhrquist, P., Vuorela, H., Julkunen-Tiitto, R., Holm, Y. (2018). Alkaloid-Rich Crude Extracts, Fractions and Piperamide Alkaloids of Piper guineense Possess Promising Antibacterial Effects. Antibiotics, 7:98
  11. Nakatsuma, A., Kiriyama, Y., Kino, K., and Ninomiya, M. (2015). Diabetes drugs that protect pancreatic β cells. Integr Mol Med. 3(1): 467-472
  12. Patel, M. B., Mishra, S. (2011). Hypoglycemic Activity Of Alkaloidal Fraction Of Tinospora Cordifolia. Phytomedicine. 15;18(12):1045-52
  13. Patel, S. B., Santani, D., Patel, V., Shah, M. (2014). Anti‑diabetic effects of ethanol extract of Bryonia laciniosa seeds and its saponins rich fraction in neonatally streptozotocin‑induced diabetic rats. Pharmacognosy Research. 7(1):92-100
  14. Purwanti, E. (2019). Efek Ekstrak Tumbuhan Suruhan (Peperomia pellucida) Terhadap Gambaran Histopatologi Ginjal Dan Kadar Glukosa Darah Pada Mencit Jantan Yang Diinduksi Aloksan. Skripsi. Jurusan Biologi Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Lampung Bandar Lampung
  15. Raghavendra H., Kekuda P. (2018). Ethnobotanical Uses, Phytochemistry And Pharmacological Activities Of Peperomia Pellucida (L.) Kunth (Piperaceae)-A Review. IJPPS. Int J Pharm Pharm Sci, 10, Issue 2: 1-8
  16. Rotenstein, L. S., Benzamin, B. A., Shivers, J. P., Yarchoan, M., Close, J., Close, K. l. (2012). The Ideal Diabetes Therapy : What Will It Look Like: How Close Are We?. Clin Diab. 30(2): 44-53.
  17. Salma, N., Paedan, J., Mamuat, L., Togubu, S. (2013). Antihiperglikemik Ekstrak Tumbuhan Suruhan (Peperomia Pellucida [L.] Kunth) Terhadap Tikus Wistar (Rattus Norvegicus L.) yang Diinduksi Sukrosa. Jurnal Ilmiah Sains. 13(2): 116-123.
  18. Togubua S., Momuat L., Jessy E. Paendonga, Salmaa N. (2013). Aktivitas Antihiperglikemik dari Ekstrak Etanol dan Heksana Tumbuhan Suruhan (Peperomia pellucida [L.] Kunth) pada Tikus Wistar (Rattus norvegicus L.) yang Hiperglikemik. Jurnal Mipa Unsrat Online. 2 (2) 109-114