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Submitted
Jan 23, 2021
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Sep 11, 2021
Published
Oct 2, 2021
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Abstract

Background: Long-term usage of paracetamol damages liver cells characterized by the increasing levels of Serum Glutamic Pyruvic Transaminase (SGPT) and Serum Glutamic Oxaloacetic Transaminase (SGOT). Figs (Ficus carica L.) leaves contain high flavonoid compounds that able to act as hepatoprotector agents which inhibited the process of liver damage. Objectives: This study aims to determine the dose characteristics and hepatoprotective activity of figs (Ficus carica L.) leaves extract. Material and Methods: The hepatoprotective activity of figs extract (Ficus carica L.) was determined by measuring SGPT & SGOT levels in rat blood. 42 rats were prepared, divided into 7 groups: normal control group, negative control given paracetamol with a dose 40 mg/200 g BW, positive control given hepamax®, base control given Na CMC, and 3 test dose groups given figs leaves extract with a dose of 40 mg/200 g BW, 80 mg BW/200 g BW and 160 mg/200 g BW. The treatment was carried out for 14 consecutive days. Paracetamol was given for 14 days, while positive control, 3 test dose groups and base control were given on day 7 to day 14.  Rats blood samples were taken through the orbital sinuses on day 1, day 5, day 10 and day 14 after treatment began. SGPT & SGOT levels were determined using spectrophotometry with analytical methods using specific SGPT & SGOT reagent kits.  Results: The results showed that the leaves extract of figs (Ficus carica L.) proved to be able to reduce the levels of SGPT & SGOT with the most potent dosage was 40 mg/200 g BW. However, the reduction of SGPT & SGOT levels were not significantly different from other treatments. Conclusions: Figs (Ficus carica L.) leaves extract showed activity as a hepatoprotective agent, based on the reduction of SGPT & SGOT levels in rat after 14 days of treatment.

Keywords

Figs Leaves Hepatoprotective Paracetamol SGPT SGOT

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Author Biographies

Muhammad Fariez Kurniawan, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Muhammadiyah Yogyakarta, Yogyakarta, Indonesia.

Program Studi Farmasi, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Muhammadiyah Yogyakarta, Yogyakarta, Indonesia.

Herdita Nugraheny Kusuma Wardany, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Muhammadiyah Yogyakarta, Yogyakarta, Indonesia.

Program Studi Farmasi, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Muhammadiyah Yogyakarta, Yogyakarta, Indonesia.

How to Cite
Kurniawan, M. F., & Wardany, H. N. K. (2021). Hepatoprotective Activity of Ethanol Extract of Figs Leaves (Ficus carica L.) with SGOT & SGPT Parameters in Sprague Dawley Female Rats Induced by Paracetamol: Efek Hepatoprotektif Ekstrak Etanol Daun Tin (Ficus carica L.) dengan Parameter SGOT dan SGPT pada Tikus Betina Sprague Dawley yang Diinduksi Paracetamol. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 7(2), 110-119. https://doi.org/10.22487/j24428744.2021.v7.i2.15443

References

  1. Abraham, P, (2005). Oxidative stress in paracetamol-induced pathogenesis: (I) renal damage. Indian J Biochem Biophys, 42: 59-62.
  2. Aghel, N., Kalantari, H., Rezazadeh, S. (2011). Hepatoprotective Effect of Ficus carica Leaf Extract on Mice Intoxicated with Carbon Tetrachloride. Iranian Journal of Pharmaceutical Research, 10 (1) : 63-68
  3. Badgujar, S.B., Patel, V.V., Bandivdekar, A.H., Mahajan, R.T. (2014). Traditional uses, Phytochemistry and Pharmacology of Ficus carica : A review. Review article. Informa Healthcare
  4. Bastiansyah, Eko. (2012). Panduan Lengkap Membaca Hasil Tes Kesehatan. Penebar Plus, Jakarta : Penebar Plus
  5. Corwin, E.Z. (2010). Buku saku patofisiologi. Terj. Dari Handbook of pathophysiology oleh Brahm, U. Penerbit Buku Kedokteran EGC, edisi revisi ke 3 Jakarta
  6. Gani, G., Fatima, T., Qadri, T., Beenish, Jan, N., Bashir, O. (2018). Phytochemistry and Pharmacological Activities of Fig (Ficus carica) : A review. International Journal of Research in Pharmacy and Pharmaceutical Sciences, 3(2) : 80-82.
  7. Harborne JB. (1987) Metode Fitokimia: Penuntun Cara Modern Menganalisis Tumbuhan. Padmawinata K, Sudiro I, penerjemah, Bandung, Penerbit ITB, Terjemahan dari: Phytohemical Methods.
  8. Kakran M, Sahoo NG, Li L. (2011). Dissolution enhancement of quercetin through nanofabrication, complexation, and solid dispersion. Colloids Surf B Biointerfaces, 88(1): 121-130.
  9. Katzung, Bertram G (2010) Farmakologi Dasar dan Klinik (terjemahan), Ed.10, Penerbit Buku Kedokteran EGC, Jakarta.
  10. Krishna MG, Pallavi E, Ravi KB, et al. (2007). Hepatoprotective activity of Ficus carica Linn. leaf extract against carbon tetrachloride-induced hepatotoxicity in rats. DARU 15:162–7
  11. Marliana, D.S., Venty, S., dan Suyono. (2005). Skrining Fitokimia dan Analisis Kromatografi Lapis Tipis Komponen Kimia Buah Labu Siam (Sechium edule Jacq. Swartz.) dalam Ekstrak Etanol. Jurnal Biofarmasi. 3(1): 29.
  12. Mawa, S., Husain, K., dan Jantan, I. (2013). Ficus carica L. (Moraceae): Phytochemistry, Traditional Uses and Biological Activities, Hindawi Publishing Corporation Evidence-Based Complementary and SGP Ternative Medicine. Review Article Vol. 2013
  13. Podolsky, D.K & Isselbacher, K.J. (2002). Tes Diagnostik pada Penyakit Hati. Dalam: Harisson Prinsip – Prinsip Ilmu Penyakit Dalam. Edisi 13. Penerbit Buku Kedokteran EGC. Jakarta.
  14. Roy CK dan Das AK. (2010) Comparative evaluation of different extracts of leaves of Psidium guajava L.. for hepatoprotective activity. Pak J Pharm 23(1):15- 20.
  15. Sahoo NG, Kakran M, Shaal LA, Li L, Müller RH, Pal M, Tan LP. (2011). Preparation and characterization of quercetin nanocrystals. J Pharm Sci, 100(6): 2379-2390
  16. Sawi., and Sleem A.A. (2010). Flavonoids And Hepatoprotective Activity Of Leaves Of Senna Surattensis (Burm.f.) In CCl4 Induced Hepatoxicity In Rats. Australian Journal Of Basic And Applied Scrences.
  17. Sangi, M., dkk. (2012). Uji Toksisitas dan Skrining Fitokimia Tepung Gabah Pelepah Aren. Jurnal Ilmiah Sains. 12 (2): 127-134
  18. Sopandi T, Wurlina. (2007). Aktivitas Imunomodulator Ekstrak Etanol dari Daun Seligi (Phyllanthus buxifolius Muell, Arg.) Sebagai Antivirus Newcatle Diseases Pada Ayam Broiler
  19. Vaya, J. Mahmood S. (2006). Flavonoid content in leaf extracts of the fig (Ficus carica L.), carob (Ceratonia siliqua L.) and pistachio (Pistacia lenticus L.). Biofactors 28 : 169-175