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Mar 2, 2021
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Oct 4, 2021
Published
Oct 4, 2021
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Abstract

Background: Hypertension plays a major role in the development of heart disease which is one of the most leading causes of death worldwide. Antihypertensives must be selected carefully to avoid affecting metabolic parameters. A risky case involving the increase of plasma glucose levels using Calcium Channel Blocker (CCB) antihypertensive, amlodipine, has been reported. Objectives: This study aims to examine the effects of CCB treatments on blood glucose levels in hypertensive patients at the Undata District General Hospital of Central Sulawesi Province. Material and Methods: This study used a cross-sectional design with a prospective approach. The instruments & materials used in this study are Accu-Chek Performa glucometer along with the patient's blood sample material. The research subjects were 31 patients who met the inclusion criteria; patients had been treated with CCB therapy for 3 months, patients were not diagnosed with diabetes mellitus, andpatients did not use drugs that might affect the blood glucose levels. Results: The results showed an average value of fasting plasma glucose (FPG) levels of hypertension patients using CCB class showed an increase from baseline of 124,619 mg/dL to 141,612 mg/dL with a difference of 16,993 mg/dL. Statistical analysis conducted also obtained a significance value of p 0,000 which indicates that the use of amlodipine can significantly increase fasting patients' plasma glucose levels. Conclusions: If observed clinically, the increasing in fasting plasma glucose values ​​falls into the category of mild to moderate hyperglycemic.

Keywords

Hypertension Calcium Channel Blocker (CCB) Fasting Glucose Plasma (FGP) Patients' Hyperglycemic

Article Details

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Author Biographies

Amelia Rumi, Tadulako University

Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Tadulako University, Palu, Indonesia

Anggun Fitriana, Tadulako University

Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Tadulako University, Palu, Indonesia

How to Cite
Rumi, A., & Fitriana, A. (2021). The Evaluation of Fasting Plasma Glucose (FPG) Levels in Hypertensive Patients Using Calcium Channel Blocker (CCB) Drugs Class in Undata Regional Hospital: Evaluasi Kadar Glukosa Plasma Puasa (GPP) pada Pasien Hipertensi Menggunakan Obat Kelas Pemblok Kanal Kalsium di Rumah Sakit Daerah Undata. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 7(2), 166-180. https://doi.org/10.22487/j24428744.2021.v7.i2.15463

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