Article Sidebar

Submitted
Aug 20, 2021
Accepted
Aug 29, 2023
Published
Oct 1, 2023
Download
PDF
Statistic
Read Counter : 241 Download : 1078

Main Article Content

Abstract

Cardiovascular disease is caused by disorders of the heart and blood vessels. One of the risk factors for cardiovascular disease is hyperuricemia, which indicates a high uric acid level in the blood, namely ≥7.0 mg / dL in men and ≥6.0 mg/ dL in women. Candersatan is one of the main line therapies that are widely used in cardiovascular patients which in previous studies were known to affect uric acid levels. This study aims to determine the effect of the use of candersatan on uric acid levels in cardiovascular patients for 3 months. This study uses a cross-sectional study with a prospective approach that is by examining uric acid levels before and after three months using candersatan and analyzed using SPSS statistical test Paired test. Of the total samples that met in the inclusion and exclusion criteria were 19 patients, the results showed an increase in uric acid levels with a significance value of 0,012 (p = ≤0.05). So it can be concluded that the average uric acid level of patients before using candersatan was 5.44 mg / dL, and the average uric acid level after using candersatan for three months was 6.30 mg / dL which means that the used of 8 mg candersatan for three months had a significant effect on the increase in uric acid levels in cardiovascular patients.

Keywords

Cardiovascular Hyperuricemia Candesartan Uric acid levels

Article Details

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

How to Cite
Rumi, A., & Budiyanto, T. D. C. (2023). Effect of Candesartan Usage on Uric Acid Levels : Pengaruh Penggunaan Candesartan Terhadap Kadar Asam Urat. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 9(2), 257-269. https://doi.org/10.22487/j24428744.2023.v9.i2.15592

References

  1. Alamsyah., Sulasri., Hasbullah., A. Fahira Nur., Vidyanto., Hermiyanti., And Betrin Ayu Wandira. (2019). Coronary Heart Disease (CHD) Patients With Oxygenation Needs Disorders. Healthy Tadulako Journal Vol. 5 No. 3.
  2. American Diabetes Association. (2015). Cardiovascular Disease and Risk Management. Diabetes Care 38 (January): S49–57. https://doi.org/10.2337/dc15-S011.
  3. Choi, Hyon K., Lucia Cea Soriano., Yuqing Zhang., And Luis A. Garciá Rodriǵuez. (2012). Antihypertensive Drugs and Risk of Incident Gout among Patients with Hypertension: Population Based Case-Control Study. BMJ (Online) 344 (7843): 1–9. https://doi.org/10.1136/bmj.d8190.
  4. Delima., Laurentia Mihardja., And Hadi Siswoyo. (2009). Prevalence and Determinant Factors of Heart Disease in Indonesia. Health Research Bulletin Volume 37 Number 3: 142-159.
  5. Dézsi, Csaba András. (2016). The Different Therapeutic Choices with ARBs. Which One to Give? When? Why?. American Journal of Cardiovascular Drugs 16 (4): 255–66. https://doi.org/10.1007/s40256-016-0165-4.
  6. Dipiro T. Joseph., Triplitt, Curtis L., Thomas Repas., Carlos Alvarez et al. (2015). Pharmacotherapy: A Pathophysiologic Approach Ninth Edition.
  7. Drazner, Mark H. (2011). The Progression of Hypertensive Heart Disease. Circulation 123 (3): 327–34. https://doi.org/10.1161/CIRCULATIONAHA.108.845792.
  8. Fachrunnisa., Sofiana Nurchayati., And Arneliwati. (2015) Factors Associated with Sleep Quality in Congestive Heart Failure Patients. JOM 2 (2).
  9. Fadlilah, Siti., Adi Sucipto., And Tia Amestiasih. (2019). Age, Gender, Smoking Behavior, and BMI Associated with the Risk of Cardiovascular Disease. Journal of Nursing 11 (1): 261–68.
  10. Flaurensia, Veronica., Magdalena Kussoy., And Ferdinand Wowiling. (2019). The habit of eating high-purine foods with uric acid levels at the health center. Journal of Nursing 7 (2): 1–7.
  11. Ghani, Lannywati., Made Dewi Susilawati., And Harli Novriani. (2016). Dominant Risk Factors for Coronary Heart Disease in Indonesia. Health Research Bulletin 44 (3): 153–64. https://doi.org/10.22435/bpk.v44i3.5436.153-164.
  12. Gikas, Aristofanis, Vaia Lambadiari, Alexios Sotiropoulos, Demosthenes Panagiotakos, and Stavros Pappas. (2016). Prevalence of Major Cardiovascular Risk Factors and Coronary Heart Disease in a Sample of Greek Adults: The Saronikos Study. The Open Cardiovascular Medicine Journal 10 (1): 69–80. https://doi.org/10.2174/1874192401610010069.
  13. Hori, Takayuki., Motoshi Ouchi., Naoyuki Otani., Masakatsu Nohara., Asuka Morita., Yusuke Otsuka., Promsuk Jutabha., Et al. (2018). The Uricosuric Effects of Dihydropyridine Calcium Channel Blockers in Vivo Using Urate Under-Excretion Animal Models. Journal of Pharmacological Sciences 136 (4): 196–202. https://doi.org/10.1016/j.jphs.2017.11.011.
  14. Jackson, Graham. (2008). Gender Differences in Cardiovascular Disease Prevention. Menopause International 14 (1): 13–17. https://doi.org/10.1258/mi.2007.007031.
  15. Jumayanti., Anggi, L.W., Eri Yanuar., And A.B.S. (2020). Quality of Life for Patients With Cardiovascular Disease In Yogyakarta. Journal of Health 13 (1), 1-12.
  16. Kabo, Peter. (2014). Coronary Heart Disease. Faculty of Medicine, University of Indonesia.
  17. Katzung, B.G and Trevor, A.J. (2015). Pharmacology Examination & Board Review Eleventh Edition. USA: McGraw-Hill.
  18. Khan, Adnan., Mohammad Hassan Shah., Sarbiland Khan., Umama Shamim., And Sanan Arshad. (2017). Serum Uric Acid Level in the Severity of Congestive Heart Failure (CHF). Pakistan Journal of Medical Sciences 33 (2): 330–34. https://doi.org/10.12669/pjms.332.11779.
  19. Kolitz, Tamara., Shachaf Shiber., Itzhak Sharabi., Asher Winder., And Gisele Zandman-Goddard. (2019). Cardiac Manifestations of Antiphospholipid Syndrome with Focus on Its Primary Form. Frontiers in Immunology 10 (MAY): 1–11. https://doi.org/10.3389/fimmu.2019.00941.
  20. Kumar Arun. (2014). Cardiovascular Diseases: Are We Overlooking Some Cardiovascular Disease Risk Factors / Markers ?. Journal of Biomedical Sciences 3 (1): 1–4. https://doi.org/10.3823/1021.
  21. Kuwabara, Masanari. (2016). Hyperuricemia, Cardiovascular Disease, and Hypertension. Pulse 3 (3–4): 242–52. https://doi.org/10.1159/000443769.
  22. Manolis, J.A., Ehud, G., Bojan, J., Andrew, J., David C.B et al. (2000). Effects Of Losartan And Candesartan Monotherapy And Losartan / Hydrochlorothiazide Combination Therapy In Patients With Mild To Moderate Hypertension. Volume 22, ISSUE 10, P1186-1203.
  23. Martiningsih and Abdul Haris. (2019). Risk of Cardiovascular Disease at Chronic Disease Management Program Participants in The Community Health Centers of Bima Town: The Correlation with Ankle Brachial Index and Obesity. Indonesian Journal of Nursing 22 (3): 200–208. https://doi.org/10.7454/jki.v22i3,880.
  24. Ministry of Health. (2018). The Main Results of Riskesdas About the Prevalence of Diabetes Mellitus in Indonesia 2018. Main Results of Riskesdas concerning the Prevalence of Diabetes Mellitus in Indonesia 2018, 8.
  25. Muiesan, M.L., Claudia, A.R., Anna P., and Massimo, S. (2016). Management of Refractory Angina Pectoris Ischaemic Heart Disease. ECRjournal, 69–76. https://doi.org/10.15420/ecr.2016.
  26. Munger, Mark A. (2011). Use of Angiotensin Receptor Blockers in Cardiovascular Protection: Current Evidence and Future Directions. P and T 36 (1): 22–32.
  27. N, Medayati., Ridwan A., Russeng S., and Stang Stang. (2018). Characteristics and Prevalence of Cardiovascular Disease Risk in Food Stalls Cooks in the Working Area of Puskesmas Tamalanrea. Journal of Health 11 (1): 30–38. https://doi.org/10.24252/keseh.v11i1.5029.
  28. Nieradko-Iwanicka, Barbara. (2018). What Is the Role of Angiotensin Receptor Blockers in Treatment of Hyperuricemia Coexisting with Arterial Hypertension ?. Rheumatology 56 (2): 106–10. https://doi.org/10.5114/reum.2018.75522
  29. Nirmalasari, Novita. (2017). Deep Breathing Exercise and Active Range of Motion Effectively Reduce Dyspnea in Congestive Heart Failure Patients. NurseLine Journal 2 (2): 159. https://doi.org/10.19184/nlj.v2i2.5940.
  30. Nishida, Yayoi., Yasuo Takahashi., Norio Susa., Nobukazu Kanou., Tomohiro Nakayama., And Satoshi Asai. (2013). Comparative Effect of Angiotensin II Type I Receptor Blockers on Serum Uric Acid in Hypertensive Patients with Type 2 Diabetes Mellitus: A Retrospective Observational Study. Cardiovascular Diabetology 12 (1): 1–8. https://doi.org/10.1186/1475-2840-12-159.
  31. Nurani Vera., Yuyun Setyorini., And Akhmad Rifai. (2018). Breathing Pattern Disorders Ineffective in Patients with Acute Myocardial Infarction (AMI). Integrated Journal of Health Sciences, Vol. 7, No. 2.
  32. Pichholiya, Meenu., Arvind Kumar Yadav., Nitin Kothari., Jameela Tahashildar., Gaurav Chhabra., And Atul Luhadia. (2016). Effect of Diet, Body Mass Index, and Proton Pump Inhibitors on Antitubercular Therapy-Induced Hyperuricemia in Patients of Tuberculosis. National Journal of Physiology, Pharmacy and Pharmacology 6 (2): 158–61. https://doi.org/10.5455/njppp.2016.6.1412201510.
  33. Ramadini, Indri. (2018). The Relationship between Physical Activity and Stress and Chest Pain in Coronary Heart Disease Patients at Rsup. Dr. M. Djamil. Human Care Journal 2 (3). https://doi.org/10.32883/hcj.v2i3.98.
  34. Rayner, Brian L., Yvonne A. Trinder, Donette Baines, Sedick Isaacs, and Lionel H. Opie. (2006). Effect of Losartan versus Candesartan on Uric Acid, Renal Function, and Fibrinogen in Patients with Hypertension and Hyperuricemia Associated with Diuretics. American Journal of Hypertension 19 (2): 208–13. https://doi.org/10.1016/j.amjhyper.2005.08.005.
  35. Ridwan, Muhammad., Yusni., And Nurkhalis. (2020). Analysis of the Characteristics of Chest Pain in Acute Coronary Syndrome Patients at the Regional General Hospital Dr. Zainoel Abidin Banda Aceh. Journal of Medical Science 1 (1): 21–26.
  36. Tian, Ting Ting., Hui Li., Sheng Jie Chen., Qing Wang., Qing Wu Tian., Bei Bei Zhang., Jie Zhu., Guo Wei He., Li Min Lun., And Chao Xuan. (2018). Serum Uric Acid as an Independent Risk Factor for the Presence and Severity of Early-Onset Coronary Artery Disease: A Case-Control Study. Disease Markers 2018. https://doi.org/10.1155/2018/1236837.
  37. Wantiyah., Mochamad Riko Saputra., And Fitrio Deviantony. (2020). Self-Efficacy And Health Status In Coronary Artery Disease Patients. Journal of Ners 15 (1).
  38. Wolff, Marissa L., Jennifer L. Cruz., Adam J. Vanderman., And Jamie N. Brown. (2015). The Effect of Angiotensin II Receptor Blockers on Hyperuricemia. Therapeutic Advances in Chronic Disease 6 (6): 339–46. https://doi.org/10.1177/2040622315596119.
  39. Zhang, J. W., W. W. Liu., Timothy A. McCaffrey., X. Q. He., W. Y. Liang., X. H. Chen., X. R. Feng., Sidney W. Fu., And M. L. Liu. (2017). Predictors of High On-Aspirin Platelet Reactivity in Elderly Patients with Coronary Artery Disease. Clinical Interventions in Aging 12: 1271–79. https://doi.org/10.2147/CIA.S138592.