Main Article Content

Abstract

Background: Geriatric patients are elderly people who have various diseases and or problems as a result of diminished organ, psychological, social, economic, and environmental functioning and who require integrated health treatments from a multidisciplinary team. Uncontrolled hypertension can lead to complications such as stroke, CHD, and kidney failure. The more incidence of complications, causing the geriatrics to get more drugs (polypharmacy). Polypharmacy is one of the risk factors for the occurrence of Potentially Inappropriate Medication (PIMs) that often occurs in geriatric patients. The 2019 Beers Criteria is one of the clear criteria that can be used to determine the prevalence of PIMs in geriatric individuals. Objectives: The objective of this study was to see if there was a correlation between the number of drugs administered to hypertensive geriatric outpatients at Dr. Soedomo General Hospital in Trenggalek and the incidence of PIMs. This study employed an observational study with an analytical approach and retrospective. This study included a sample of 85 prescriptions for outpatient geriatric hypertension outpatient at Dr. Soedomo General Hospital in the period October - December 2020 taken using the purposive sampling technique. Data were analyzed using the C contingency coefficient correlation test. Results: 67,1% of prescriptions contained ≥ 5 kinds of drugs and 32,9% of prescriptions contained < 5 kinds of drugs. Based on the incidence of PIMs, there were 97.6% of prescriptions for PIMs and 2.4% of prescriptions without PIMs. The C contingency coefficient correlation test shows the correlation coefficient (r) of 0.216 with a positive direction and p-value = 0.041. Conclusions: The number of drugs has a significant correlation and can cause the incidence of PIMs in geriatric patients with weak correlation strength. Collaboration between pharmacists and doctors is needed to provide the best therapy to patients, to maximize the role of pharmacists in monitoring drug use in geriatric patients at Dr. Soedomo Hospital in Trenggalek.

Keywords

Geriatrics Polypharmacy PIMs Beers Criteria

Article Details

Author Biographies

Sri Suhartatik, Dr. Soedomo Regional General Hospital, Trenggalek

Head of Pharmacy Installation, Dr. Soedomo Regional General Hospital, Trenggalek

Rimawati Rimawati, Dr. Soedomo Regional General Hospital, Trenggalek

Pharmacist, Dr. Soedomo Regional General Hospital, Trenggalek

How to Cite
Widyaningrum, E. A., PDW, K. S., Astuti, L. W., Suhartatik, S., Rimawati, R., & Sari, E. K. (2021). Correlation Between the Number of Drugs Prescribed and Potentially Inappropriate Medication (PIMS) Based on Beers Criteria in Geriatric Hypertension Outpatients at Dr. Soedomo Hospital in Trenggalek: Hubungan Jumlah Obat terhadap Potentially Inappropriate Medication (PIMS) Berdasarkan Beers Criteria pada Pasien Hipertensi Geriatri Rawat Jalan Rsud Dr. Soedomo Trenggalek. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 7(3), 238-250. https://doi.org/10.22487/j24428744.2021.v7.i3.15671

References

  1. Abdulah, R., dan Barliana, MI. (2015). ‘Penggunaan Obat yang Berpotensi Tidak Tepat pada Populasi Geriatri di Kota Bandung’. Jurnal Farmasi Klinik Indonesia, vol. 4, no. 3, hh. 226 – 234.
  2. Alldredge, B.K., Corelli, R.L., Ernst, M.E., Guglielmo, B.J., Jacobson, P.A., Kradjan, W.A. (2013). Koda-Kimble & Young’s Applied Therapeutics The Clinical Use of Drugs, Edisi 10, Lippincott Williams & Wilkins, Pennsylvania, United States of America.
  3. American Geriatrics Society. (2015). ‘American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults’. Journal of the American Geriatrics Society (JAGS). vol. 63, no. 11.
  4. American Geriatrics Society. (2019). ‘American Geriatrics Society 2019 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults’. Journal of the American Geriatrics Society (JAGS).
  5. Amrulloh, F.M. dan Utami, N., (2016) ‘Hubungan Konsumsi OAINS terhadap Gastritis’. Jurnal Majority, vol. 5, hh. 18–21.
  6. Badan Pusat Statistik. (2019), Statistik Penduduk Lanjut Usia, Badan Pusat Statistik, Jakarta.
  7. Charfi, R., Sassi M.B., Gaies E., Jebabli N., Daghfous R., dan Trabelsi, S. (2020). ‘Digoxin Therapeutic Drug Monitoring: Age Influence and Adverse Events’, La Tunisie Medicale, vol. 98, no. 1.
  8. Darmawan, E., Hidayat A., Perwitasari, D.A dan Kusumawardani, N. (2020). ‘Pharmacist Intervention can Reduce the Potential Use of Inappropriate Drugs Medications in Indonesian Geriatric Patients’, Journal of Applied Pharmaceutical Science. vol.10, no.1. hh. 88 – 95.
  9. Dasopang, E.S., Harahap, U., Lindarto, D. (2015). ‘Polifarmasi dan Interaksi Obat Pasien Lanjut Usia Rawat Jalan dengan penyakit Metabolik’, Jurnal Farmasi Klinik Indonesia, vol.4, no.4, hh. 235 – 241.
  10. Direktorat Bina Farmasi Komunitas dan Klini. (2004), Pedoman pelayanan farmasi (Tatalaksana Terapi Obat) Untuk Pasien Geriatri, Departemen Kesehatan RI, Jakarta.
  11. Ehle M, Patel C, Giugliano RP. (2011). ‘Digoxin: Clinical Highlights: A Review of Digoxin and Its Use in Contemporary Medicine’, Crit Pathw Cardiol, vol.10, no.2, hh.93-98.
  12. Fixen, Danielle R., dan Robet L. (2019) ‘2019 AGS Beers Criteria for older adult’, American Pharmacist Association. Page II.
  13. Ittaman, S.V., VanWormer J.J., Rezkalla, S.H.. (2014). The role of aspirin in the prevention of cardiovascular disease'. Clin Med Res, vol.12, hh. 147–54.
  14. Kementerian Kesehatan Republik Indonesia. (2016). Penyelenggaraan Pelanyanan Kesehatan Geriatri di Rumah Sakit - Peraturan Menteri Kesehatan Republik Indonesia Nomor 79 Tahun 2014, Kementerian Republik Indonesia, Jakarta.
  15. Kementerian Kesehatan Republik Indonesia. (2018) Hasil Utama Riskesdas 2018. Kementerian Republik Indonesia, Jakarta.
  16. Kersten, H. and Wyller, TB. (2014). ‘Anticholinergic Drug Burden in Older People’s Brain - How Well is it Measured ?’, Basic and Clinical Pharmacology and Toxicology, vol.114, no.2, hh. 151–159.
  17. Muharni, S., Aryanti, F., dan Fadillah, R. (2019). ‘Analisis Jumlah Obat Terhadap Potentially Inappropriate Medication (PIMs) Berdasarkan Beers Criteria 2019 Pada Pasien Hipertensi Geriatri di Puskesmas Sidomulyo Kota Pekanbaru’. Jurnal Penelitian Farmasi Indonesia, vol.7, no.2, hh. 70 – 76.
  18. Negara, Y.R., Machlaurin, A. dan Rachmawati, E. (2016). ‘Potensi Penggunaan Obat yang Tidak Tepat pada Peresepan Pasien Geriatri Rawat Jalan di RSUD dr. Soebandi Jember Berdasarkan Beers Criteria’, E-jurnal Pustaka Kesehatan, vol.4, no.1, hh. 14 – 19.
  19. Samuel, M.J. (2015). ‘American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults’, Journal of the American Geriatrics Society, vol.3, no.11, hh. 2227–2246.
  20. Supartondo dan Govinda RA.(2014). ‘Pedoman Memberi Obat pada Pasien Geriatri serta Mengatasi Masalah Polifarmasi’, dalam: Sudoyo AW, Setiyohadi B, Alwi I, Simadibrata M, Setiati S, editor (penyunting). Buku Ajar Ilmu Penyakit dalam, edk 6, Internal Publishing. Jakarta.
  21. Ulfa, N.M., Arfiana, N. (2020), ‘Efektivitas Penggunaan Oral Antidiabetes Kombinasi Glimepiride Dengan Pioglitazone Pada Pasien Dibetes Mellitus Tipe 2’, Journal of Pharmacy and Science, vol. 5, no.1.
  22. Yogita, KS., dan Priti, D.P. (2013), ‘Measuring Inappropriate Prescriptions In Geriatric Population: Overview Of Various Screening Tools’. International Journal of Medical Research and Health Sciences, vol.2, no.3, hh. 636-642.
  23. Zhuo, Y., Meng, D., Chen, F., Wu, Z., Wang,B., Wang, S. et al. (2020), ‘Inhibitory Effect of Imperatorin on the Pharmacokinetics of Diazepam In Vitro and In Vivo’. Frontiers in Pharmacology, vol.11.
  24. Zulkarnaini, A. dan Martini, R.D. (2019). ‘Gambaran Polifarmasi Pasien Geriatri di beberapa Poliklinik RSUP Dr. M. Djamil Padang. Jurnal Kesehata Andalas’, vol.8, no.1.