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Mar 16, 2022
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Oct 31, 2022
Published
Oct 31, 2022
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Abstract

Background: Parang romang (Boehmeria virgata) has an antihyperlipidemic effect, but the use of herbs commonly has limitations with poor solubility in water, causing failure in the clinical phase due to low bioavailability. Bioavailability can be increased by nanotechnologies, one of them is nanoemulsion. Objectives: This study aimed to determine the pharmacokinetic profile and effectiveness of antihyperlipidemic activity of nanoemulsion preparation and ethanol extract of parang romang leaves. Methods: Pharmacokinetic study was done with 10 rats that each given 100 mg/kg BW of nanoemulsion and ethanol extract from parang romang leaves. The blood was taken at 0.5; 1; 1.5; 2; 2.5; 3; 3.5; 4 hours to measure tmax, Cpmax, and AUC. Study of antihyperlipidemic was done with 30 rats divided into 5 groups with normal control group I given Na CMC suspension, group II negative control given high fat feed + streptozotocin, group III positive control given high fat feed + streptozotocin and simvastatin 0.9 mg/ kg BW, group IV given high fat feed + streptozotocin + ethanol extract of parang romang leaves 100 mg/kg BW and group V given  high fat feed + streptozotocin + nanoemulsion of ethanol extract of parang romang 100 mg/kg BW. The blood was then taken on day 0,14,21, 28 and 35. Results: The results of the pharmacokinetic profile test showed that the values ​​of tmax, Cpmax, and AUC for nanoemulsions and extract were respectively; 0.5 hours, 96.68 g/ml and 297.57 and 1-hour, 15.44 g/ml and 93.53. The statistical results obtained a significant value (P < 0,05) which showed a significant effect between nanoemulsion and ethanol extract of parang romang to reduce cholesterol levels Conclusions: There are differences in pharmacokinetic profile and antihyperlipidemic effectiveness between nanoemulsion preparations and ethanol extracts from parang romang leaves.

Keywords

Pharmacokinetic profile Antihyperlidipemic Effectiveness Nanoemulsion Ethanol extract of Parang romang

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Author Biography

Magfirah Magfirah, Sekolah Tinggi Ilmu Farmasi Pelita Mas (STIFA-PM) Palu

Department of pharmacy

How to Cite
Magfirah, M. (2022). Pharmacokinetic Profile and Antihyperlipidemic Effectiveness of Nanoemulsion and Ethanol Extract of Parang Romang (Boehmeria virgata) Leaves: Profil Farmakokinetik dan Efektifitas Antihiperlipidemia Sediaan Nanoemulsi dan Ekstrak Etanol dari Daun Parang Romang (Boehmeria virgata). Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 8(2), 162-172. https://doi.org/10.22487/j24428744.2022.v8.i2.15842

References

  1. Chaturvedi, M., Sinhal, A., Kumar, M., & Saifi, A. (2011). Recent development in novel drug delivery systems of herbal drugs. International Journal of Green Pharmacy, 5(2), 87-92.
  2. Diarti, M. W., Tatontos, E. Y., & Mianti. (2018). Efek Tepung Biji Melon (Cucumis Melo L.) Terhadap Kadar Kolesterol Total Hewan Coba Tikus Putih Jantan (Rattus Norvegicus) Galur Wistar. Jurnal Kesehatan Prima, 12(2),152-161
  3. Edi Kamal, S., & Herman, H. (2019). Efektivitas Pemberian Ekstrak Daun Suji (Pleomele angustifolia) Terhadap Kadar Kolesterol Total Pada Tikus Putih (Rattus norvergicus). Jurnal Farmasi Sandi Karsa, 5(2), 110-115.
  4. Lovianie, M., Shoimah, D., & Yanor, A. (2019). Pengaruh Pemberian Sediaan Mikroemulsiekstrak Bawang Dayak (Eleutherine Bulbosa (Mill.) Urb) Dan Mikroemulsi Daun Bungur (Lagerstronemia Speciosa L. Pers.) Terhadap Penurunan Kadar Kolesterol Total Pada Tikus Yang diinduksi pakan Tinggi Kolesterol. 3(1),(55-60.
  5. Kintoko, Balfas R.F, Ustrina N. (2018). Effect of Spirulina Platensis on Level Analysis, Histopathology, Insulin and Glut-4 Expression in Wistar Rats Induced by Streptozotosin. Jurnal Ilmu Kefarmasian Indonesia, 16(2), 238-247.
  6. K. Gurpret, & S. K. Singh. (2018). Review of Nanoemulsion Formulation and Characterization Techniques. Indian Journal of Pharmaceutical Sciences, 80(5). 781-789
  7. Magfirah, M. (2018). Pengaruh Pemberian Ekstrak Etanol Daun Parang Romang (Boehmeria Virgata) Secara Subkronis Oral Terhadap Profil Hematologi Dan Biokimia Dari Hati Dan Ginjal Tikus Putih (Rattus Novergicus). (Unpublished doctoral thesis) universitas Hasanuddin.
  8. Magfirah, Utami IK. Optimization and Characterization of Formulation SelfNanoemulsifying Drug Delivery System Ethanol Extract of Romang Parang Leaves (Boehmeria Virgata). Asian J Pharm Clin Res. 2021;14(1):207–12
  9. Magfirah (2021). Uji Efek Antioksidan Formulasi Nanoemulsi Ekstrak Etanol Daun Parang Romang (Boehmeria virgata). Jurnal Ilmiah Pharmacy 8 (1), 46-53.
  10. Magfirah, Indah Kurnia Utami, Syafika Alaydrus. (2020). Efek Ekstrak Etanol Rumput Laut (Eucheumacottonii J. Agardh) terhadap Kadar Kolesterol dan Obesitas Pada Tikus Putih Jantan. Jurnal Jamu Indonesia. 5 (3): 98-105
  11. Paramitha, TA. (2017) Uji Aktivitas Ekstrak Etanol Akar Parang Romang (Boehmeria virgata (Forst.) Guill) Terhadap Penurunan Kolesterol Pada Mencit (Mus musculus) (Published doctoral thesis) universitas Alauddin
  12. Rusdi, M. (2017). Isolasi dan karakterisasi senyawa aktif fraksi n-heksan daun parang romang (Boehmeria virgate (Forst) Guill) terhadap sel kanker hela. Unpublished doctoral thesis) universitas Hasanuddin.
  13. Sun, S., Wang, Y., Wu, A., Ding, Z., & Liu, X. (2019). Influence Factors of the Pharmacokinetics of Herbal Resourced Compounds in Clinical Practice. Evidence-Based Complementary and Alternative Medicine, 2019, 1–16.
  14. Tandi, J., Lalu, R., Nuraisyah, S., Magfirah., Kenta, YS., & Nobertson, R. (2020). Uji Potensi Nefropati Diabetes Daun Sirih Merah (Piper croatum Ruiz & Pav) pada Tikus Putih Jantan (Rattus norvegicus). Kovalen: Jurnal Riset Kimia, 6(3): 239-251.
  15. Tanggu Rame, M. M., Adeodatus, M. A., & Mbulang, Y. K. A. (2021). Antihypercholesterolemic Activity of Forest Basil (Ocimum sanctum) Stem and Root Extract in White Rats. Jurnal Farmasi & Sains Indonesia, 4(1), 36-43.