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May 26, 2022
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Oct 27, 2022
Published
Oct 1, 2023
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Abstract

Background: Type 2 diabetes mellitus (DM) is a chronic disease which requires long-term therapy. Medication adherence plays an important role for therapeutic success in patients with T2DM. Antidiabetic usage pattern might involve with some problems related to medication adherence. Objectives: The aim of this study was to analyze the association between antidiabetic usage pattern with medication adherence. Material and Methods: This observational study was conducted cross-sectionally involving 90 participants of T2DM  outpatient at Private Hospital in Buleleng Bali during July-September 2020. Patients were included if aged ≥18 years, received the same antidiabetic for three months before the study, signed informed consent, and provided with complete medical record data. Patients were excluded if appeared to be unwell, pregnant or breastfeeding. Demographic data and antidiabetic usage patterns were collected retrospectively based on the patient's medical records. Probabilistic Medication Adherence Scale (ProMAS) questionnaire was used to assess medication adherence. Data were analyzed with Kruskal-Wallis test. Results: The results showed that 55.6% patients were male, aged 46-65 years (61.1%), education predominantly by elementary school (37.8%), had suffered from DM for 5-10 years (46.7%), with comorbidities (50%), and without complications (77.8%). The antidiabetic usage pattern was dominated by a combination of two antidiabetics (53.3%). Most patients (42.2%) showed moderate-high medication adherence. There was no statistically significant association between antidiabetic usage pattern and medication adherence (p=0.275). Conclusions: A higher rate of medication adherence was found in patients taking combination of two antidiabetics compared to combination of three or four antidiabetics.

Keywords

Type 2 diabetes mellitus Antidiabetic pattern Medication adherence

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How to Cite
Ratnasari, P. M. D., Ardeliani, I. G. A. I., Yuliawati, A. N., & Kurnianta, P. D. M. (2023). Association Between Antidiabetic Pattern with Medication Adherence in Type 2 Diabetes Patients at Buleleng Hospital: Hubungan Antara Pola Penggunaan Antidiabetik dengan Kepatuhan Pengobatan Pada Pasien Diabetes Melitus Tipe 2 Di Salah Satu Rumah Sakit Swasta Buleleng Bali. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 9(2), 132-146. https://doi.org/10.22487/j24428744.2023.v9.i2.15908

References

  1. Abebaw, M., Messele, A., Hailu, M., & Zewdu, F. (2016). Adherence and Associated Factors towards Antidiabetic Medication among Type II Diabetic Patients on Follow-Up at University of Gondar Hospital , Northwest Ethiopia. Hindawi Publishing Corporation, 2016, 1–8.
  2. Akın, S., & Bölük, C. (2020). Prevalence of comorbidities in patients with type–2 diabetes mellitus. Primary Care Diabetes, 14(5), 431–434.
  3. Almira, N., Arifin, S., & Rosida, L. (2019). Faktor-Faktor Yang Berhubungan Dengan Perilaku Kepatuhan Minum Obat Anti Diabetes Pada Penderita Diabetes Melitus Tipe 2 Di Puskesmas Teluk Dalam Banjarmasin. Homeostasis, 2(1), 9–12.
  4. American Diabetes Association. (2019). American Diabetes Association: Standards of Medical Care in Diabetes 2019. The Journal of Clinical and Applied Research and Education, 42(1), 90–93.
  5. Aminde, L. ., Tindong, M., Ngwasiri, C., Aminde, J., Njim, T., Fondong, A., & Takah, N. (2019). Adherence to antidiabetic medication and factors associated with non-adherence among patients with type-2 diabetes mellitus in two regional hospitals in Cameroon. BMC Endocrine Disorders, 19(1), 1–9.
  6. Araya, E. ., Gebrezgabiher, H. ., Tekulu, G. ., Alema, N. ., Getnet, D., & Gebur, H. (2020). Medication Non-Adherence and Associated Factors Among Diabetic Patients Visiting General Hospitals in the Eastern Zone of Tigrai , Northern Ethiopia. Patient Preference and Adherence, 14, 2071–2083.
  7. Attyia, A. ., El, R. ., Abu, M. ., Al-batanony, M. ., & Ahamed, A. . (2013). Compliance of diabetic patients with the prescribed clinical regimen. 26(1), 54–57.
  8. Azizah, M. I. (2019). Penyakit Mitokondria : Review Penyakit Mitokondria : Review. December, 0–9.
  9. Bagonza, J., Rutebemberwa, E., & Bazeyo, W. (2015). Adherence to anti diabetic medication among patients with diabetes in eastern Uganda ; a cross sectional study. BMC Health Services Research, 15, 1–7.
  10. Benedetti, M., & Orsini-Federici, M. (2010). Treatment of type 2 diabetes with combined therapy: what are the pros and cons? Diabetes Care, 31(2).
  11. Datak, G., & Febriani, I. (2020). Hubungan Komunikasi Interpersonal Perawat Terhadap Kepatuhan Minum Obat Pasien Diabetes Melitus Tipe 2 Relation of Nurse Interpersonal Communication to Compliance in Taking Medication of Type 2 Diabetes Mellitus Patients. Jurnal Kesehatan Poltekkes Kemenkes RI Pangkalpinang, 8(1), 56–62.
  12. Dinas Kesehatan Provinsi Bali. (2019). Profil Kesehatan Provinsi Bali 2018. Dinas Kesehatan Provinsi Bali, 1–129.
  13. Edi, I. G. M. S. (2015). Faktor-Faktor Yang Mempengaruhi Kepatuhan Pasien Pada Pengobatan: Telaah Sistematik. Jurnal Ilmiah Medicamento, 1(1), 1–8.
  14. Engler, C., Leo, M., Pfeifer, B., Juchum, M., Chen-Koenig, D., Poelzl, K., Schoenherr, H., Vill, D., Oberdanner, J., Eisendle, E., Middeldorf, K., Heindl, B., Gaenzer, H., Bode, G.,
  15. Kirchmeyr, K., Ladner, G., Rieger, L., Koellensperger, U., Schwaiger, A., … Ebenbichler, C. (2020). Long-term trends in the prescription of antidiabetic drugs: Real-world evidence from the Diabetes Registry Tyrol 2012-2018. BMJ Open Diabetes Research and Care, 8(1), 1–9.
  16. Fatimah, R. N. (2015). Diabetes Melitus Tipe 2. J Majority, 4(5), 93–101.
  17. Felea, M. ., Covrig, M., Mircea, I., & Naghi, L. (2014). Socioeconomic Status and Risk of Type 2 Diabetes Mellitus among an Elderly Group Population in Romania. Procedia Economics and Finance, 10(14), 61–67.
  18. Fiagbe, J., Bosoka, S., Opong, J., Takramah, W., Axame, W., Owusu, R., Adjuik, M., Tarkang, E., & Kweku, M. (2017). Prevalence of controlled and uncontrolled diabetes mellitus and associated factors of controlled diabetes among diabetic adults in the hohoe municipality of Ghana. Diabetes Management, 7(5), 343–354.
  19. Gamayanti, V., Ratnasari, N., & Bhargah, A. (2018). Pola penggunaan insulin pada pasien diabetes mellitus tipe 2 di poli penyakit dalam RSU Negara Periode Juli – Agustus 2018. Intisari Sains Medis, 9(3), 68–73.
  20. García-Pérez, L. E., Álvarez, M., Dilla, T., Gil-Guillén, V., & Orozco-Beltrán, D. (2013). Adherence to therapies in patients with type 2 diabetes. Diabetes Therapy, 4(2), 175–194.
  21. Gordon, J., McEwan, P., Idris, I., Evans, M., & Puelles, J. (2018). Treatment choice, medication adherence and glycemic efficacy in people with type 2 diabetes: A UK clinical practice database study. BMJ Open Diabetes Research and Care, 6(1), 1–9.
  22. Hapsari, P. (2014). Hubungan Antara Kepatuhan Penggunaan Obat Dan Keberhasilan Terapi Pada Pasien Diabetes Mellitus Instalasi Rawat Jalan Di RSUD Dr. Moewardi Surakarta. Skripsi, Fakultas F(Universitas Muhammadiyah Surakarta).
  23. Heissam, K., Abuamer, Z., & El-Dahshan, N. (2015). Patterns and obstacles to oral antidiabetic medications adherence among type 2 diabetics in Ismailia, Egypt: a cross section study. PanAfrican Medical Journak, 20, 1–7.
  24. Hestiana, D. W. (2017). Faktor-Faktor Yang Berhubungan Dengan Kepatuhan Dalam Pengelolaan Diet Pada Pasien Rawat Jalan Diabetes Mellitus Tipe 2 Di Kota Semarang. Journal of Health Education, 2(2), 138–145.
  25. International Diabetes Federation (IDF). (2019). International Diabetes Federation. In The Lancet (Vol. 266, Issue 6881).
  26. Javanbakht, M., Abolhasani, F., Mashayekhi, A., Baradaran, H. ., & Jahangiri, N. . (2012). Health Related Quality of Life in Patients with Type 2 Diabetes Mellitus in Iran: A National Survey. PLoS ONE, 7(8), 1–9.
  27. Kamuhabwa, A. R., & Charles, E. (2014). Predictors of poor glycemic control in type 2 diabetic patients attending public hospitals in Dar es Salaam. Drug, Healthcare and Patient Safety, 6, 155–165.
  28. Kardas, P., Lewek, P., & Matyjaszczyk, M. (2013). Determinants of patient adherence: A review of systematic reviews. Frontiers in Pharmacology, 4(91), 1–16.
  29. Kartika, I. G. A. ., Lestari, A. A. ., & Swastini, D. A. (2013). Perbandingan Profil Penggunaan Terapi Kombinasi Insulin pada Pasien Diabetes Mellitus Tipe 2 di Unit Rawat Inap Rumah Sakit Umum Pusat Sanglah. Jurnal Farmasi Udayana, 2(2), 62–69.
  30. Kassahun, T., Eshetie, T., & Gesesew, H. (2016). Factors associated with glycemic control among adult patients with type 2 diabetes mellitus: A cross-sectional survey in Ethiopia Endocrine Disorders. BMC Research Notes, 9(1), 1–6.
  31. Kemenkes RI. (2019). Profil Kesehatan Indonesia 2018 [Indonesia Health Profile 2018].
  32. Khangura, D., Kurukulasuriya, L. ., Connell, A. ., & Sowers, J. . (2018). Diabetes and Hypertension: Clinical Update. American Journal of Hypertension, 31(5).
  33. Khunti, N., Khunti, N., & Khunti, K. (2019). Adherence to type 2 diabetes management. The British Journal of Diabetes, 19(2), 99–104.
  34. Kirkman, M., Rowan, M. ., Levin, R., Fonseca, V. ., Schmittdiel, J. ., Herman, W. ., & Aubert, R. . (2015). Determinants of Adherence to Diabetes Medications : Findings From a Large Pharmacy Claims Database. Diabetes Care, 1–6.
  35. Kleppe, M., Lacroix, J., Ham, J., & Midden, C. (2015). The development of the ProMAS: A probabilistic medication adherence scale. Patient Preference and Adherence, 9, 355–367.
  36. Lukito, J. I. (2020). Tinjauan atas Terapi Insulin. Ckd-288, 47(7), 525–529.
  37. Makhmari, A. ., Ullah, M. ., Sulieman, F., & Al Saadi, K. . (2018). Identifying the Prevalence and Risk Factors Associated With Uncontrolled Diabetes ( Type 2 ) in Al Buraimi Governorate , Sultanate of Oman. Global Journal of Health Science, 10(11), 39–45.
  38. Mokolomban, C., Wiyono, W. ., & Mpila, D. . (2018). Kepatuhan Minum Obat Pada Pasien Diabetes Melitus Tipe 2 Disertai Hipertensi Dengan Menggunakan Metode MMAS-8. Pharmacon Jurnal Ilmiah Farmasi, 7(4), 69–78.
  39. Nanda, O. D., Wiryanto, B., & Triyono, E. A. (2018). Hubungan Kepatuhan Minum Obat Anti Diabetik dengan Regulasi Kadar Gula Darah pada Pasien Perempuan Diabetes Mellitus. Amerta Nutrition, 2(4), 340.
  40. Nandini, Gali, A., & Muraraiah, S. (2020). Assessment of Factors Influencing Adherence to Antidiabetic Drugs Among Patients with Type 2 Diabetes Mellitus at a Tertiary Care Hospital in India. Pharmacology and Clinical Pharmacy Research, 5, 1–7.
  41. Nordström, A., Hadrévi, J., Olsson, T., Franks, P. W., & Nordström, P. (2016). Higher prevalence of type 2 diabetes in men than in women is associated with differences in visceral fat mass. Journal of Clinical Endocrinology and Metabolism, 101(10), 3740–3746.
  42. Nowakowska, M., Zghebi, S. S., Ashcroft, D. M., Buchan, I., Chew-Graham, C., Holt, T., Mallen, C., Van Marwijk, H., Peek, N., Perera-Salazar, R., Reeves, D., Rutter, M. K., Weng, S. F., Qureshi, N., Mamas, M. A., & Kontopantelis, E. (2020). Erratum: The comorbidity burden of type 2 diabetes mellitus: Patterns, clusters and predictions from a large English primary care cohort. BMC Medicine, 18(1), 1–10.
  43. Pahlawati, A., & Nugroho, P. S. (2019). Hubungan Tingkat Pendidikan dan Usia dengan Kejadian Diabetes Melitus di Wilayah Kerja Puskesmas Palaran Kota Samarinda Tahun 2019. Borneo Student Research (BSR), 1(1), 1–5.
  44. Pantuzza, L. L., Ceccato, M. das G. B., Silveira, M. R., Junqueira, L. M. R., & Reis, A. M. M. (2017). Association between medication regimen complexity and pharmacotherapy adherence: a systematic review. European Journal of Clinical Pharmacology, 73(11), 1475–1489.
  45. Pardede, T. ., Rosdiana, D., & Christianto, E. (2017). Gambaran Pengendalian Diabetes Melitus Berdasarkan Parameter Indeks Massa Tubuh dan Tekanan Darah di Poli Rawat Jalan Penyakit Dalam RSUD Arifin Achmad Pekanbaru. Jurnal Online Mahasiswa Fakultas Kedokteran, 4(1), 13–14.
  46. Petrenchik, L., & Loh, F. (2020). Factors Affecting Non-Insulin Antidiabetic Drug Adherence in Patients with Type 2 Diabetes : A Systematic Review. Diabetes & Obesity Journal, 12(5), 117–127.
  47. Pratama, I. P. Y., Andayani, T. M., & Kristina, S. A. (2019). Knowledge, Adherence and Quality of Life Among Type 2 Diabetes Mellitus Patients. International Research Journal Of Pharmacy, 10(4), 52–55.
  48. Punthakee, Z., Goldenberg, R., & Katz, P. (2018). Definition, Classification and Diagnosis of Diabetes, Prediabetes and Metabolic Syndrome. Canadian Journal of Diabetes, 42, S10–S15.
  49. Rajpathak, S. N. (2015). Prevalence of comorbidities high in type 2 diabetes. Healio Enndcorinology, 1.
  50. Rana, M. ., Islam, M. ., & Akter, J. (2019). Medication adherence to Type 2 diabetic patients hospitalized at a tertiary care hospital. Journal of Health Sciences Research, 9(3), 159–167.
  51. Rasdianah, N., Martodiharjo, S., Andayani, T., & Hakim, L. (2016). The Description of Medication Adherence for Patients of Diabetes Mellitus Type 2 in Public Health Center Yogyakarta. Indonesian Journal of Clinical Pharmacy, 5(4), 249–257.
  52. Rathish, D., Hemachandra, R., Premadasa, T., Ramanayake, S., Rasangika, C., Roshiban, R., & Jayasumana, C. (2019). Comparison of medication adherence between type 2 diabetes mellitus patients who pay for their medications and those who receive it free : a rural Asian experience. Journal of Health, Population and Nutrition, 38(4), 1–8.
  53. Restada, E. J. (2016). Hubungan Lama Menderita Dan Komplikasi Diabetes Melitus Dengan Kualitas Hidup Pada Penderita Diabetes Melitus Di Wilayah Puskesmas. Jurnal Keperawatan, 3(1), 5–20.
  54. Romadhon, R., Saibi, Y., & Nasir, N. (2020). Kepatuhan Terhadap Pengobatan Pasien Diabetes Melitus Tipe 2 di Puskesmas Jakarta Timur. Jurnal Farmasi Galenika, 6(1), 94–103.
  55. Rosyid, F. N. (2017). Etiology, pathophysiology, diagnosis and management of diabetics’ foot ulcer. International Journal of Research in Medical Sciences, 5(10), 4206.
  56. Sappo, N., Rahmawati, D., & Ramadhan, A. . (2017). Karakteristik Dan Pola Penggunaan Obat Anti Diabetik Pada Pasien Diabetes Melitus Tipe 2 Di RSUD Abdul Wahab Sjarahranie. Universitas Mulawarman, 41–47.
  57. Thapar, R., Holla, R., Kumar, N., Aithal, S., & Karkera, S. (2020). Factors in fl uencing adherence to anti-diabetes medications among type 2 diabetes patients attending tertiary care hospitals in Mangaluru. Clinical Epidemiology and Global Health, 8(4), 1089–1093.
  58. Wexler, D. ., Nathan, D. ., & Multer, J. . (2021). Initial management of hyperglycemia in adults with type 2 diabetes mellitus. Up to Date, 20.
  59. Zoungas, S., Woodward, M., Li, Q., Cooper, M. E., Hamet, P., Harrap, S., Heller, S., Marre, M., Patel, A., & Poulter, N. (2014). Impact of age, age at diagnosis and duration of diabetes on the risk of macrovascular and microvascular complications and death in type 2 diabetes. Diabetologia, 57, 2465–2474.