Article Sidebar

Submitted
Jul 20, 2022
Accepted
Sep 9, 2022
Published
Oct 20, 2022
Download
PDF
Statistic
Read Counter : 359 Download : 325

Main Article Content

Abstract

Background: Yellow root (Arcangelisia flava Merr.) is a native Indonesian plant that contains alkaloids, phenolics, flavonoids, saponins, tannins and berberine. This plant is proven to have antimicrobial, antioxidant, antihyperlipidemic, and anticancer activity. However, the effect on body weight, clinical symptoms and toxic symptoms has not been studied yet. Objectives: Accordingly, the objective of this research was to determine the effect of Arcangelisia flava Merr. extract with the multilevel maceration method on parameters of body weight, clinical symptoms and toxic symptoms in male rats. Material and Methods: A total of 16 male rats aged 6-8 weeks weighing 20-40 grams were divided into 4 groups. The control group was only given 1% sodium-carboxymethyl cellulose (CMC-Na), while the treatment group was given Arcangelisia flava Merr. extract at doses of 800, 900, and 1000 mg/kgBW orally for 28 days. At week 1 to week 4, body weight, clinical symptoms and toxic symptoms were observed for male rats. Result: Observations of toxic symptoms and symptoms showed that there were several symptoms that appeared in male rats and changes in body weight there were no significant differences from t0 to t1, t0 to t2, t0 to t3, and t0 to t4 for each treatment (p>0,05). Conclusions: The administration of Arcangelisia flava Merr. extract at doses of 800, 900, and 1000mg/kgBW for 28 days did not affect weight gain or loss, but these extracts did have an effect on symptoms in test animals such as straight fur and strange behavior.

Keywords

Toxicity Test Subchronic 28 days Multilevel Maceration Extract Arcangelisia flava Merr

Article Details

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

How to Cite
Aprilianti, R. G., Permataningtyas, T., & Wardana, F. Y. (2022). Oral Subchronic Toxicity Test of Yellow Root Ethanol Extract (Arcangelisia flava Merr.) In Rats (Mus musculus): Uji toksisitas subkronik oral ekstrak etanol akar kuning (Arcangelisia flava Merr.) pada Mencit (Mus musculus). Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 8(2), 154-161. https://doi.org/10.22487/j24428744.2022.v8.i2.15961

References

  1. Budiyanto, A. (2015). Potensi Antioksidan, Inhibitor Tirosinase, dan Nilai Toksisitas dari Beberapa Spesies Tanaman Mangrove di Indonesia. Bogor: Institute Pertanian Bogor.
  2. Dewatisari, W. F., Rumiyanti, L. dan Rakhmawati, I. (2018). Rendemen dan Skrining Fitokimia pada Ekstrak Daun Sanseviera sp. Jurnal Penelitian Pertanian Terapan. 17(3). pp. 197–202.
  3. Kaharap, A. D., Mambo, C. dan Nangoy, E. (2016). Uji Efek Antibakteri Ekstrak Batang Akar Kuning (Arcangelisia flava Merr.) terhadap Bakteri Staphylococcus aureus dan Escherichia Coli. Jurnal e-Biomedik. 4(1). doi: 10.35790/ebm.4.1.2016.12138.
  4. Loomis. (1978). Toxicology. III. Edited by Donatus. Lea and Febriger.
  5. Nurhayati, T. D., Aryanti dan Nurjanah. (2009). Kajian Awal Potensi Ekstrak Spons sebagai Antioksidan. Jurnal Kelautan Nasional. 2(2). pp. 43–51.
  6. Pudjiastuti, Y. A. N. (2009). Uji Gelagat dan Uji Analgesik Ekstrak Etanol Daun Kembang Sungsang (Gloriosa superba L.) pada Hewan Coba. pp. 1–7.
  7. Rachmawati, E. dan Ulfa, E. U. (2018). Uji Toksisitas Subkronik Ekstrak Kayu Kuning (Arcangelisia flava Merr) terhadap Hepar dan Ginjal. Global Medical and Health Communication. 6(1). pp. 1–6. doi: http://dx.doi.org/10.29313/gmhc.v6i1.2203.
  8. Ratnasari, D. dan Handayani, R. P. (2018). Skrining Fitokimia dan Uji Stabilitas Sediaan Sirup Kayu Kuning (Arcangelisia Flava) untuk Memelihara Kesehatan. Journal of Holistic and Health Sciences. 2(1). pp. 7–13. doi: 10.51873/jhhs.v2i1.18.
  9. Riwanti, P., Izazih, F. dan Amaliyah. (2020). Pengaruh Perbedaan Konsentrasi Etanol pada Kadar Flavonoid Total Ekstrak Etanol 50,70 dan 96% Sargassum polycystum dari Madura. Journal of Pharmaceutical Care Anwar Medika. 2(2). pp. 82–95.
  10. Sari, A. K., Alfian, R., Musiam, S., Prasdianto, dan Renndy. (2018). Penetapan Kadar Fenolik dan Flavonoid Total Ekstrak Metanol Kayu Kuning (Arcangelisia flava Merr) dengan Metode Spektrofotometri UV-Visibel. Jurnal Insan Farmasi Indonesia. 1(2). pp. 210–217.
  11. Tjay, T. H. dan Kirana, R. (2001). Obat-obat Penting. Jakarta: PT. Elex Media Komputindo.
  12. Wood, J. (1999). Gout and Management. The Pharmaceutical Journal.