Article Sidebar

Submitted
Jul 18, 2022
Accepted
Sep 11, 2022
Published
Oct 2, 2022
Download
PDF
Statistic
Read Counter : 353 Download : 343

Main Article Content

Abstract

Background: Liver disease is generally still a high prevalence in Indonesia. One of drug-induced liver injury is paracetamol. Banana peel (Musa paradisiaca Sapientum) has flavonoid compounds that could increasing the production of glutathione enzymes in the liver. Objectives: This research aims to determine the activity of banana peel induced by paracetamol. This research is an experimental with pre and post test control group design method. Material and Methods: This research is an experimental with pre and post test control group design method. Group I was given 0.05% Na CMC as negative control, group II was given paracetamol 180 mg/kgBB as induction control group, group III was given banana peel extract at dose 700 mg / kgBB, group IV was given banana peel extract at dose 1400 mg/kgBB, and group V was given banana peel extract at dose 2100 mg/kgBW. Results: The liver damage can be measured by SGOT/SGPT serum levels of rats. SPSS data analysis with Paired sample T test obtained the value of p = 0.003 for SGOT (serum glutamic oxaloacetic transaminase) and p = 0.000 for SGPT. Conclusions: Both SGOT and SGPT values have p <0.05 which indicates that banana peel (Musa paradisiaca Sapientum) methanol extract has hepatoprotector effect on paracetamol-induced rats.

Keywords

Musa paradisiaca Sapientum peel Hepatoprotector SGOT SGPT

Article Details

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

How to Cite
Pusmarani, J., Ifaya, M., & Putri, R. J. (2022). Hepatoprotector Effect of Banana Peel (Musa paradisiaca Sapientum) on Paracetamol Induced Rats: Efek Hepatoprptektor Kulit Pisang Raja pada Tikus Yang Diinduksi Parasetamol. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 8(2), 109-116. https://doi.org/10.22487/j24428744.2022.v8.i2.15968

References

  1. Boušová, I., Skálová, L., 2012. Inhibition and induction of glutathione S-transferases by flavonoids: possible pharmacological and toxicological consequences. Drug Metab. Rev. 44, 267–286.
  2. Chabuck, Z.A.G., Al-Charrakh, A.H., Hindi, N.K.K., Hindi, S.K.K., 2013. Antimicrobial effect of aqueous banana peel extract, Iraq. Res. Gate. Pharm. Sci 1, 73–75.
  3. De‐Giorgio, F., Lodise, M., Chiarotti, M., d’Aloja, E., Carbone, A., Valerio, L., 2013. Possible fatal acetaminophen intoxication with atypical clinical presentation. J. Forensic Sci. 58, 1397–1400.
  4. Engelking, L.R., 2010. Textbook of veterinary physiological chemistry, updated 2/e. Academic Press.
  5. Fristiohady, A., Wahyuni, W., Yusuf, M.I., Malik, F., Purnama, L.O.M.J., Bafadal, M., Leorita, M., Jabar, A., Malaka, M.H., Sahidin, I., 2020. Hepatoprotective activity of etlingera elatior (jack) RM Smith extract against CCl4-induced hepatic toxicity in male wistar rats. Res. J. Pharm. Technol. 13, 4585–4590.
  6. Ghanem, C.I., Pérez, M.J., Manautou, J.E., Mottino, A.D., 2016. Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity. Pharmacol. Res. 109, 119–131.
  7. Ishitsuka, Y., Kondo, Y., Kadowaki, D., 2020. Toxicological property of acetaminophen: the dark side of a safe antipyretic/analgesic drug? Biol. Pharm. Bull. 43, 195–206.
  8. Issa, M.T., Agbon, A.N., Balogun, S.U., Mahdi, O., Bobbo, K.A., Ayegbusi, F.O., 2018. Hepatoprotective effect of methanol fruit pulp extract of Musa paradisiaca on carbon tetrachloride-induced liver toxicity in Wistar rats. J Exp Clin Anat 17, 1–7.
  9. Kapadia, S.P., Pudakalkatti, P.S., Shivanaikar, S., 2015. Detection of antimicrobial activity of banana peel (Musa paradisiaca L.) on Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans: An in vitro study. Contemp. Clin. Dent. 6, 496.
  10. Lancaster, E.M., Hiatt, J.R., Zarrinpar, A., 2015. Acetaminophen hepatotoxicity: an updated review. Arch. Toxicol. 89, 193–199.
  11. Mazaleuskaya, L.L., Sangkuhl, K., Thorn, C.F., FitzGerald, G.A., Altman, R.B., Klein, T.E., 2015. PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet. Genomics 25, 416.
  12. McGill, M.R., Jaeschke, H., 2013. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm. Res. 30, 2174–2187.
  13. Mishra, S., Aeri, V., Katare, D.P., 2014. Hepatoprotective medication for liver injury. J. Pharm. Pharm. Sci. 3, 891–932.
  14. Nurrahma, H.A., Meliala, A., Narwidina, P., Herwiyanti, S., 2021. Hepatoprotective Effect of Banana Peel Flour on Histological and Liver Function in Diabetic Rats. Indones. J. Pharm. 529–538.
  15. Pandit, A., Sachdeva, T., Bafna, P., 2012. Drug-induced hepatotoxicity: a review. J. Appl. Pharm. Sci. 233–243.
  16. Pholmoo, N., Bunchorntavakul, C., 2019. Characteristics and outcomes of acetaminophen overdose and hepatotoxicity in Thailand. J. Clin. Transl. Hepatol. 7, 132.
  17. Piotrowska, N., Klukowska-Rötzler, J., Lehmann, B., Krummrey, G., Haschke, M., Exadaktylos, A.K., Liakoni, E., 2019. Presentations related to acute paracetamol intoxication in an urban emergency department in Switzerland. Emerg. Med. Int. 2019.
  18. Pusmarani, J., Putri, R.J., Dewi, C., Purwono, S., Ikawati, Z., 2019. Non Specific and Specific Parameter Standardization Of Banana Peel (Musa paradisciata Sapientum) and Andrographis Paniculata. Int. Summit Sci. Technol. Humanit. 658–664.
  19. Pusmarani, J., Putri, R.J., Dewi, C., Ramadhan, D.S.F., Nasir, H., Riska, Purwono, S., Ikawati, Z., 2020. Antioxidant Activity Assay of Combination of Purified Extract of Banana Peel (Musa Paradisiaca Sapientum) and Andrographis Paniculata Leaves. J. Glob. Pharma Technol. 12, 98–104.
  20. Rafita, I.D., Lisdiana, L., Marianti, A., 2015. Pengaruh ekstrak kayu manis terhadap gambaran histopatologi dan kadar sgot-sgpt hepar tikus yang diinduksi parasetamol. Life Sci. 4.
  21. Rosida, A., 2016. Pemeriksaan laboratorium penyakit hati. Berk. Kedokt. 12, 123–131.
  22. Roy, S.D., Das, S., Shil, D., Dutta, K.N., 2012. Herbal hepatoprotective agents: a review. World J. Pharma. Res 1, 87–99.
  23. Rubin, J.B., Hameed, B., Gottfried, M., Lee, W.M., Sarkar, M., Group, A.L.F.S., 2018. Acetaminophen-induced acute liver failure is more common and more severe in women. Clin. Gastroenterol. Hepatol. 16, 936–946.
  24. Shiffman, S., Battista, D.R., Kelly, J.P., Malone, M.K., Weinstein, R.B., Kaufman, D.W., 2018. Prevalence of exceeding maximum daily dose of paracetamol, and seasonal variations in cold‐flu season. Br. J. Clin. Pharmacol. 84, 1250–1257.
  25. Singh, A., Bhat, T.K., Sharma, O.P., 2011. Clinical biochemistry of hepatotoxicity. J Clin. Toxicol S 4, 495–2161.
  26. Singhal, M., Ratra, P., 2013. Antioxidant activity, total flavonoid and total phenolic content of Musa acuminate peel extracts. Glob. J. Pharmacol. 7, 118–122. https://doi.org/10.5829/idosi.gjp.2013.7.2.72158
  27. Someya, S., Yoshiki, Y., Okubo, K., 2002. Antioxidant compounds from bananas (Musa Cavendish). Food Chem. 79, 351–354.
  28. Victor, P., 2016. Atlas Histologi diFiore dengan Korelasi Fungsional. 12th ed. dr. Y. Joko S et al., editor. Jakarta: ; 2016, 12th ed. Penerbit Buku Kedokteran EGC.
  29. Wang, X., Wu, Q., Liu, A., Anadón, A., Rodríguez, J.-L., Martínez-Larrañaga, M.-R., Yuan, Z., Martínez, M.-A., 2017. Paracetamol: overdose-induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro. Drug Metab. Rev. 49, 395–437.
  30. Yoon, E., Babar, A., Choudhary, M., Kutner, M., Pyrsopoulos, N., 2016. Acetaminophen-induced hepatotoxicity: a comprehensive update. J. Clin. Transl. Hepatol. 4, 131.