Article Sidebar

Submitted
Nov 1, 2022
Accepted
May 12, 2023
Published
Oct 1, 2023
Download
PDF
Statistic
Read Counter : 271 Download : 202

Main Article Content

Abstract

Background: The yield of active compound in a plant can be affected by the extraction method, such as variety of solvent and extraction technique used. Objectives: This study aimed to optimize the yield of Lannea coromandelica leaf extract using several types of solvent and extraction techniques and evaluate the antioxidant activity of the extracts. Material and Methods: This study used a variety of solvent like distilled water, ethanol, n-hexane, and ethyl acetate with maceration, reflux, and sonication extraction techniques. The extract obtained was calculated for the percent yield and analyzed for their antioxidant activity using the DPPH method by UV -Vis Spectrophotometry with 523.5 nm maximum wavelength. The antioxidant activity was analyzed by factorial design analysis in Minitab 21 software. Results: The highest percentage yields was obtained from the extract with ethanol solvent, followed by distilled water, ethyl acetate and n-hexane. The highest extraction techniques was obtained from reflux and followed by maceration and sonication extracts. Analytical factorial design analysis showed that the linearity of solvent variation and extraction technique had a significant effect (P>0.05). From the analysis, it was found that there was a significant difference between the effect of the solvent on the antioxidant activities compared to the extraction technique. The extracts obtained have a very strong antioxidant activity against DPPH radicals. T Conclusions: L. coromandelica plant aquadest extract has potential to be developed in optimalization extraction method.

Keywords

Optimization Antioxidant Lannea coromandelica

Article Details

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

How to Cite
AR, M. A., Hikma, N., Yasir, B., Asril Burhan, A., & Khairuddin, K. (2023). Optimization of Extraction Lannea coromandelica for Antioxidant Activity using Analytical Factorial Design Approach : Optimisasi Ekstraksi Tanaman Lannea coromandelica Sebagai Antioksidan dengan Pendekatan Analisis design Faktorial. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 9(2), 224-232. https://doi.org/10.22487/j24428744.2023.v9.i2.16106

References

  1. Adiwibowo, M. T. (2020). Pengaruh Metode dan Waktu Ekstraksi Terhadap Kualitas dan Kuantitas Saponin Dalam Ekstrak Buah, Daun, dan Tangkai Daun Belimbing Wuluh (Avverhoa bilimbi L.) Untuk Aplikasi Detergen. 9(2), 44–50.
  2. Astuti, A. D., Yasir, B., Subehan, & Alam, G. (2019). Comparison of Two Varieties of Plectranthus scutellarioides Based on Extraction Method, Phytochemical Compound, and Cytotoxicity. Journal of Physics: Conference Series, 1341(7). https://doi.org/10.1088/1742-6596/1341/7/072012
  3. Azzahrah, N. F., Jamaluddin, A. W., & Adikurniawan, Y. M. (2019). Efektivitas Patch Sederhana Dari Ekstrak Daun Kayu Jawa (Lannea coromandelica (Houtt.) Merr.) Terhadap Penyembuhan Luka Sayat Pada Tikus (Rattus norvegicus). Jurnal Ilmiah As-Syifaa, 11(2), 169–180. https://doi.org/10.33096/jifa.v11i2.531
  4. Baso, F. F. (2022). Uji Daya Hambat Antibakteri Ekstrak Etanol Daun Tammate (Lannea Coromandelica) Terhadap Beberapa Bakteri Patogen. 003(002), 53–59.
  5. Chandra, B., Asra, R., & Mevia, N. A. (2022). Perbedaan Ekstraksi Daun Teratai (Nymphaea Pubescens Willd) Sebagai Fungsi Aktivitas Antioksidan. Jurnal Farmasi Higea, 14(1), 28. https://doi.org/10.52689/higea.v14i1.434
  6. Faisal, A. P., Nasution, P. R., & Wakidi, R. F. (2022). Aktivitas Antioksidan dari Daun Bintangur (Calophyllum inophyllum L.) terhadap Radikal Bebas DPPH (1,1 Difenil-2-pikrihidrazil. Jurnal Riset Kefarmasian Indonesia, 4(1), 1–10. http://jurnalfarmasi.or.id/index.php/jrki/article/view/200
  7. Gusungi, D. E., Maarisit, W., Hariyadi, H., & Potalangi, N. O. (2020). Studi Aktivitas Antioksidan Dan Antikanker Payudara (MCF-7) Ekstrak Etanol Daun Benalu Langsat Dendrophthoe pentandra. Biofarmasetikal Tropis, 3(1), 166–174. https://doi.org/10.55724/j.biofar.trop.v3i1.274
  8. Muin, R. (2021). Uji Efektifitas Gel Ekstrak Etanol Kulit Batang Kayu Jawa (Lannea coromandelica) Pada Kelinci (Oryctolagus Cuniculus) Sebagai Obat Luka Bakar. Journal of Pharmaceutical Science and Herbal Technology, 6(1), 4–7. https://doi.org/10.35892/jpsht.v6i1.509
  9. Nurhasnawati, H., Handayani, F., & Sukarmi. (2017). Sokletasi Terhadap Aktivitas Antioksidan Ekstrak Etanol Daun Jambu Bol ( Syzygium malaccense L .). Jurnal Ilmiah Manuntung, 3(1), 91–95.
  10. Rusdi, M., Hasan, T., Ardillah, A., & Evianti, E. (2018). Perbandingan Metode Ekstraksi terhadap Kadar Flavonoid Total dan Aktivitas Antioksidan Batang Boehmeria virgata. ad-Dawaa’ Journal of Pharmaceutical Sciences, 1(1), 16–24. https://doi.org/10.24252/djps.v1i1.6426
  11. Utami, N. F., Nurdayanty, S. M., Susanto, & Suhendar, U. (2015). Pengaruh Berbagai Metode Ekstraksi Pada Penentuan Kadar Flavanoid Ekstrak Etanol Daun Iler (Plectranthus scutellariodes). Paper Knowledge . Toward a Media History of Documents, 3(April), 49–58.