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Submitted
Feb 19, 2023
Accepted
Aug 23, 2023
Published
Oct 1, 2023
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Abstract

Background: Diabetes Mellitus (DM) is a health problem that affects more than 400 million people worldwide. Type 1 diabetes is an autoimmune disease characterized by damage of pancreatic cells followed by hyperglycemia and oxidative stress. Propolis is one of the natural ingredients of bee products. Propolis is known to have bioactive compounds that are rich in flavonoids, phenolic and antioxidant properties so that it has potential as an antidiabetic. Objectives: This writing aims to determine the activity of propolis in test animals of Type 1 DM model. Material and Methods: This research method uses a literature study using type 1 diabetic as inclusion criteria in journal screening. Keywords used include propolis, diabetes and hyperglycemia. Literature is obtained through an electronic data base, such as Google Scholar, PubMed, Scopus and Science Direct. Results: Based on the articles that have been collected, that Type 1 DM causes inflammation which is characterized by decreased immune function due to increased levels of IL-6, IL-1β and TNF-α. Propolis can reduce levels of pro-inflammatory cytokines, prevent the inflammatory process in diabetes and have hypoglycemic activity.  Conclusions: The conclusion of the reviewed article that propolis from honey bee has effectiveness to improve the function of body cells and reduce diabetes complication.

Keywords

Propolis Type 1 diabetes Hyperglycemic Cytokines

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How to Cite
Nisa, K., & Kustiawan, P. M. (2023). Effectiveness of Honey Bees Propolis Extract in The Treatment of Type 1 Diabetes Mellitus: Efektifitas Ekstrak propolis Lebah Madu pada Pengobatan Diabetes Tipe 1. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 9(2), 247-256. https://doi.org/10.22487/j24428744.2023.v9.i2.16297

References

  1. Ahad, Amjid, Ajaz Ahmad Ganai, Mohd Mujeeb, and Waseem Ahmad Siddiqui. 2014. “Chrysin, an Anti-Inflammatory Molecule, Abrogates Renal Dysfunction in Type 2 Diabetic Rats.” Toxicology and Applied Pharmacology 279(1):1–7. doi: 10.1016/j.taap.2014.05.007.
  2. Alvarez-Suarez, José M. 2017. Bee Products - Chemical and Biological Properties.
  3. Anjum, Syed Ishtiaq, Amjad Ullah, Khalid Ali Khan, Mohammad Attaullah, Hikmatullah Khan, Hussain Ali, Muhammad Amjad Bashir, Muhammad Tahir, Mohammad Javed Ansari, Hamed A. Ghramh, Nuru Adgaba, and Chandra Kanta Dash. 2019. “Composition and Functional Properties of Propolis (Bee Glue): A Review.” Saudi Journal of Biological Sciences 26(7):1695–1703. doi: 10.1016/j.sjbs.2018.08.013.
  4. Azid, Mohd Zulkhairi, Erny Sabrina, and Rosliza Jajuli. 2020. “Proses Penulenan Propolis Lebah Kelulut ( Purification Process of Stingless Bee Propolis ) Proses Penulenan Propolis Lebah Kelulut.” (January).
  5. Balingui, Cecile Fabiola, Talla Ernest Rodrigue, Ngassoum Martin Benoît, Talla Emmanuel, and Awalou Oumarou. 2021. “Phenolic and Flavonoid Contents, DPPH Antiradical Scavenging and Antidiabetic Activities of the Hydromethanolic Extract of Nyambaka Propolis.” The Journal of Phytopharmacology 10(5):357–61. doi: 10.31254/phyto.2021.10513.
  6. Al Ghamdi, Ahmad A., Gamal Badr, Wael N. Hozzein, Ahmed Allam, Noori S. Al-Waili, Mohammed A. Al-Wadaan, and Olivier Garraud. 2015. “Oral Supplementation of Diabetic Mice with Propolis Restores the Proliferation Capacity and Chemotaxis of B and T Lymphocytes towards CCL21 and CXCL12 by Modulating the Lipid Profile, the pro-Inflammatory Cytokine Levels and Oxidative Stress.” BMC Immunology 16(1):1–14. doi: 10.1186/s12865-015-0117-9.
  7. Granados-Pineda, Jessica, Norma Uribe-Uribe, Patricia García-López, María del Pilar Ramos-Godinez, J. Fausto Rivero-Cruz, and Jazmin Marlen Pérez-Rojas. 2018. “Effect of Pinocembrin Isolated from Mexican Brown Propolis on Diabetic Nephropathy.” Molecules 23(4):1–19. doi: 10.3390/molecules23040852.
  8. Gülçin, Ilhami, Ercan Bursal, M. Hilal Şehitoĝlu, Mine Bilsel, and Ahmet C. Gören. 2010. “Polyphenol Contents and Antioxidant Activity of Lyophilized Aqueous Extract of Propolis from Erzurum, Turkey.” Food and Chemical Toxicology 48(8–9):2227–38. doi: 10.1016/j.fct.2010.05.053.
  9. Harijanto, Elbert Aldrin, and Anna Maria Dewajanti. 2017. “Optimalisasi Pemberian Streptozotocin Beberapa Dosis Terhadap Peningkatan Kadar Gula Darah Tikus Sprague Dawley.” Jurnal Kedokteran Meditek 23(63):12–18.
  10. Hartanti, Jatie K. Pudjibudojo, Lisa Aditama, and Retno Pudji Rahayu. 2013. “Pencegahan Dan Penanganan Diabetes Mellitus.” Fakultas Psikologi Universitas Surabaya 96.
  11. Hernández Zarate, María Susana, María del Rosario Abraham Juárez, Abel Cerón García, César Ozuna López, Abner Josué Gutiérrez Chávez, José de Jesús Nezahualcóyotl
  12. Segoviano Garfias, and Fidel Avila Ramos. 2018. “Flavonoids, Phenolic Content, and Antioxidant Activity of Propolis from Various Areas of Guanajuato, Mexico.” Food Science and Technology (Brazil) 38(2):210–15. doi: 10.1590/fst.29916.
  13. Huang, Shuai, Cui Ping Zhang, Kai Wang, George Q. Li, and Fu Liang Hu. 2014. “Recent Advances in the Chemical Composition of Propolis.” Molecules 19(12):19610–32. doi: 10.3390/molecules191219610.
  14. Husna, Fauzul, Franciscus D. Suyatna, Wawaimuli Arozal, and Erni H. Purwaningsih. 2019. “Model Hewan Coba Pada Penelitian Diabetes.” Pharmaceutical Sciences and Research 6(3):131–41. doi: 10.7454/psr.v6i3.4531.
  15. Katsarou, Anastasia, Soffia Gudbjörnsdottir, Araz Rawshani, Dana Dabelea, Ezio Bonifacio, Barbara J. Anderson, Laura M. Jacobsen, Desmond A. Schatz, and Ake Lernmark. 2017. “Type 1 Diabetes Mellitus.” Nature Reviews Disease Primers 3:1–18. doi: 10.1038/nrdp.2017.16.
  16. Malik, Salma, Kapil Suchal, Sana Irfan Khan, Jagriti Bhatia, Kamal Kishore, Amit Kumar Dinda, and Dharamvir Singh Arya. 2017. “Apigenin Ameliorates Streptozotocin-Induced Diabetic Nephropathy in Rats via MAPK-NF-ĸB-TNF-α and TGF-Β1-MAPK-Fibronectin Pathways.” American Journal of Physiology - Renal Physiology 313(2):F414–22. doi: 10.1152/ajprenal.00393.2016.
  17. Marzel, Rivaldi. 2020. “Terapi Pada DM Tipe 1.” Jurnal Penelitian Perawat Profesional 3(1):51–62. doi: 10.37287/jppp.v3i1.297.
  18. Oladayo, Mustafa Ibrahim. 2016. “Nigerian Propolis Improves Blood Glucose, Glycated Hemoglobin A1c, Very Low-Density Lipoprotein, and Highdensity Lipoprotein Levels in Rat Models of Diabetes.” Journal of Intercultural Ethnopharmacology 5(3):233–38. doi: 10.5455/jice.20160502065029.
  19. Oldoni, Tatiane Luiza Cadorin, Sheila C. Oliveira, Suelen Andolfatto, Mariéli Karling, Matheus A. Calegari, Ricardo Y. Sado, Fabiana M. C. Maia, Severino M. Alencar, and Vanderlei A. Lima. 2015. “Chemical Characterization and Optimization of the Extraction Process of Bioactive Compounds from Propolis Produced by Selected Bees Apis Mellifera.” Journal of the Brazilian Chemical Society 26(10):2054–62. doi: 10.5935/0103-5053.20150186.
  20. Ozdal, Tugba, Fatma Duygu Ceylan, Nazife Eroglu, Muammer Kaplan, Elmas Oktem Olgun, and Esra Capanoglu. 2019. “Investigation of Antioxidant Capacity, Bioaccessibility and LC-MS/MS Phenolic Profile of Turkish Propolis.” Food Research International 122(May):528–36. doi: 10.1016/j.foodres.2019.05.028.
  21. Parwata, Made Oka Adi. 2016. “Antioksidan.” Kimia Terapan Program Pascasarjana Universitas Udayana (April):1–54.
  22. El Rabey, Haddad A., Madeha N. Al-Seeni, and Amal S. Bakhashwain. 2017. “The Antidiabetic Activity of Nigella Sativa and Propolis on Streptozotocin-Induced Diabetes and Diabetic Nephropathy in Male Rats.” Evidence-Based Complementary and Alternative Medicine 2017. doi: 10.1155/2017/5439645.
  23. Ridwan, Ahmad, Ayu Nirmala Sari, and Ramadhani Eka Putra. 2015. “The Potency of Trigona’s Propolis Extract as Reactive Oxygen Species Inhibitor in Diabetic Mice.” Journal of Mathematical and Fundamental Sciences 47(3):261–68. doi: 10.5614/j.math.fund.sci.2015.47.3.4.
  24. Rivera-Yañez, Nelly, Mario Rodriguez-Canales, Oscar Nieto-Yañez, Manuel Jimenez-Estrada, Maximiliano Ibarra-Barajas, M. M. Canales-Martinez, and M. A. Rodriguez-Monroy. 2018. “Hypoglycaemic and Antioxidant Effects of Propolis of Chihuahua in a Model of Experimental Diabetes.” Evidence-Based Complementary and Alternative Medicine 2018. doi: 10.1155/2018/4360356.
  25. Samadi, Nazli, Hassan Mozaffari-Khosravi, Masoud Rahmanian, and Mohsen Askarishahi. 2017. “Effects of Bee Propolis Supplementation on Glycemic Control, Lipid Profile and Insulin Resistance Indices in Patients with Type 2 Diabetes: A Randomized, Double-Blind Clinical Trial.” Journal of Integrative Medicine 15(2):124–34. doi: 10.1016/S2095-4964(17)60315-7.
  26. Sameni, Hamid Reza, Parisa Ramhormozi, Ahmad Reza Bandegi, Abbas Ali Taherian, Majid Mirmohammadkhani, and Manouchehr Safari. 2016. “Effects of Ethanol Extract of Propolis on Histopathological Changes and Anti-Oxidant Defense of Kidney in a Rat Model for Type 1 Diabetes Mellitus.” Journal of Diabetes Investigation 7(4):506–13. doi: 10.1111/jdi.12459.
  27. Saputra, Nengah Tegar, I. Nyoman Suartha, and Anak Agung Gde Oka Dharmayudha. 2018. “Agen Diabetagonik Streptozotocin Untuk Membuat Tikus Putih Jantan Diabetes Mellitus.” Buletin Veteriner Udayana 10(2):116. doi: 10.24843/bulvet.2018.v10.i02.p02.
  28. Shahinozzaman, Md, Nozomi Taira, Takahiro Ishii, Mohammad A. Halim, Md Amzad Hossain, and Shinkichi Tawata. 2018. “Anti-Inflammatory, Anti-Diabetic, and Anti-Alzheimer’s Effects of Prenylated Flavonoids from Okinawa Propolis: An Investigation by Experimental and Computational Studies.” Molecules 23(10):1–18. doi: 10.3390/molecules23102479.
  29. Stephen Irudayaraj, Santiagu, Christudas Sunil, Veeramuthu Duraipandiyan, and Savarimuthu Ignacimuthu. 2012. “Antidiabetic and Antioxidant Activities of Toddalia Asiatica (L.) Lam. Leaves in Streptozotocin Induced Diabetic Rats.” Journal of Ethnopharmacology 143(2):515–23. doi: 10.1016/j.jep.2012.07.006.
  30. Tanvir, E. M., Md Asif Hasan, Shariful Islam Nayan, Tamanna Islam, Tania Ahmed, Md Sakib Hossen, Rasheda Perveen, Shahnaz Rahman, Raihana Afroz, Rizwana Afroz, and Muhammed Alamgir Zaman Chowdhury. 2019. “Ameliorative Effects of Ethanolic Constituents of Bangladeshi Propolis against Tetracycline-Induced Hepatic and Renal Toxicity in Rats.” Journal of Food Biochemistry 43(8):1–11. doi: 10.1111/jfbc.12958.
  31. Webber, Sara. 2013. International Diabetes Federation. Vol. 102.