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Submitted
Apr 10, 2023
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Oct 24, 2023
Published
Oct 24, 2023
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Abstract

Background: Traditional medicine plays a role in alternative treatment systems for diabetes mellitus. Objectives: This study aimed to screen the secondary metabolite of the ethanol extract from robusta coffee (Coffea canephora Pierre) seeds. We aimed to clarify the effects of these extracts on blood glucose, urea, and creatinine levels in Streptozotocin-Induced Diabetic Rats. Material and Methods: Phytochemical screening of extracts was carried out qualitatively according to standard methods. The rats were administered ethanol extracts of C. canephora Pierre seeds at doses of 100, 200, and 300 mg/kg body weight for 28 days. Blood glucose, urea, and creatinine levels were then compared between the control and diabetes groups. Results: The ethanol extract of C. canephora Pierre seeds contains alkaloids, flavonoids, saponins, and tannins. Group doses of 100-300 mg/kg body weight can significantly reduce blood glucose,  urea, and creatinine levels. It can be concluded that the ethanol extract C. canephora Pierre seeds is a potential source of antidiabetic. Conclusions: The ethanol extract of C. canephora Pierre seeds shows potential as an antidiabetic agent.

Keywords

Coffea canephora Pierre ex A. Froehner, Blood Glucose Levels, Ureum Levels, Creatinine Levels, streptozotocin, White Rats.

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How to Cite
Tandi, J., Marsella, M., Suarsana, I. M. A., Dewi, N. P., Magfirah, M., Handayani, T. W., & Kanan, M. (2023). The Effectiveness of Ethanol Extract of Robusta Coffee Seeds on Blood Glucose, Urea, and Creatinine Levels of Male White Rats Induced by Streptozotocin: Efektivitas Ekstrak Etanol Biji Kopi Robusta terhadap Kadar Glukosa Darah, Urea, dan Kreatinin Tikus Putih Jantan yang Diinduksi Streptozotocin. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 9(2), 284-292. https://doi.org/10.22487/j24428744.2023.v9.i2.16352

References

  1. Amalia, F. F. (2020). The Antibacterial Activity Of Robusta Coffee In Accelerating The Incidence Of Wound Healing In Diabetic Ulcers. 2017(1), 1–9.
  2. Azhari, D. M., Yuliet, Y., &; Khaerati, K. (2016). Activity Test Of White Oyster Mushroom Powder (Pleurotus ostreatus (Jacq.) P.Kumm) Against Blood Glucose Levels In Animal Models Of Hypercholesterolemia-Diabetes. Galenika Journal of Pharmacy (e-Journal), 2(2), 96–102.
  3. Hasanuddin, R., &; Abdillah, N. (2021). The Analysis of the Chlorogenic Acid in the Ethanol Fraction of Robusta Coffee Beans and Its Effect on Glucose Levels in Wistar Rats. 15(2), 118–124.
  4. Kaddafi, M., Mariska, R. P., Hermawan, R. S., Jannah, R., Adha, K. Al, &; Jannah, T. H. (2022). The introduction of diabetes mellitus along with its treatment with cherry leaves. Journal of Mother's Hope Service (JPHI), 4(1), 1.
  5. Mangiwa, S., &; Maryuni, A. E. (2019). Phytochemical Screening and Antioxidant Test of Arabica Roasted Coffee Bean Extract (Coffea arabica) from Wamena and Moanemani, Papua. Papua Journal of Biology, 11(2), 103–109.
  6. Maulana, A., Putra, P., Aulia, D., &; Wahyuni, A. (2017). Activity Test of Wuluh Star Fruit Leaf Ethanol Extract (Averrhoa bilimbi L.) Against alloxan-induced decrease in blood glucose levels of male white mice. Ibn Sina's Scientific Journal, 2(2), 263–269.
  7. Nurmawati, T. (2017). Study of Physiological Response and Blood Sugar Levels in White Rats (Rattus Norvegicus) Exposed to Streptozotocin (STZ). Journal of Ners and Midwifery, 4(3), 244–247.
  8. Patala, R., Utami, K., &; Wahyuni, S. (2021). Potential of red betel leaf extract against streptozotocin-induced male white rat pancreatic histopathology. Pharmacological Journal of Pharmacy, XVIII(2).
  9. Saputra, N. T., Suartha, I. N., &; Dharmayudha, A. A. G. O. (2018). Streptozotocin Diabetagonic Agent to Make Male White Rats Diabetes Mellitus. Udayana Veterinary Bulletin, 10(2), 116.
  10. Sari, R. P., &; Putra, A. M. P. (2018). Test of the activity of ethanol extract of Chinese petai seeds (Leucaena leucocephala) against a decrease in blood glucose levels in glucose-induced male white mice. Ibn Sina's Scientific Journal (JIIS): Pharmaceutical and Health Sciences, 3(1), 37–44.
  11. Shiyan, S., Herlina, H., Arsela, D., & Latifa, E. (2017). Aktivitas Antidiabetes Ekstrak Etanolik Daun Kopi Robusta (Coffea canephora) Pada Tikus Diabetes Tipe 2 Yang Diberi Diet Lemak Tinggi Dan Sukrosa. Jurnal Farmasi Sains Dan Praktis, 3(2), 39–46.
  12. Suiraoka, I... (2018). Degenerative diseases, recognizing, preventing and reducing risk factors 9 degenerative diseases.
  13. Tandi, J, Sudar, C. P., Mutahharah, A., & ... (2021). Test of the effect of taro tuber ethanol extract (Colocasia esculenta (L) Schott) on reducing glucose, ureum and creatinine levels of male white rats (Rattus novergicus.... Mandala Journal ..., 7(2).
  14. Tandi, Joni, Lalu, R., Magfirah, Kenta, Y. S., &; Nobertson, R. (2020). Test of Potential Nephropathy of Red Betel Leaf Diabetes (Piper croatum, Ruiz &; Pav) in Male White Rats (Rattus norvegicus). COVALENT: Journal of Chemical Research, 6(3), 239–251.
  15. Tandi, Joni, Rahmawati, R., Isminarti, R., &; Lapangoyu, J. (2018). The effect of yellow pumpkin seed extract on glucose, cholesterol and pancreatic histopathologic features of hypercholesterolemia-diabetic rats. Talenta Conference Series:Tropical Medicine (TM), 1(3), 144–151.
  16. Tandi, J., Danthy, R., & Kuncoro, H. (2019). Effect of Ethanol Extract from Purple Eggplant Skin (Solanum melongena L) On Blood Glucose Levels and Pancreatic? Cells Regeneration on White Rats Male Hypercholesterolemia Diabetic. Research Journal of Pharmacy and Technology, 12(6), 2936-2942.
  17. Tandi, J., Handayani, T. W., & Widodo, A. Qualitative And Quantitative Determination Of Secondary Metabolites And Antidiabetic Potential Of Ocimum basilicum L. Leaves Extract. Rasayan J. Chem., 14(1), 622-628(2021)
  18. Tandi, J., Handayani, T. W., Tandebia, M., & Wijaya, J. A. (2020). Effect of Parkia speciosa Hassk Peels Extract on Total Cholesterol Levels of Hypercholesterolemia Rats. Indian Journal of Forensic Medicine & Toxicology, 14(4).
  19. Tandi, J., Sutrisna, I. N. E., Pratiwi, M., & Handayani, T. W. (2020). Potential Test of Nephropathy Sonchus arvensis L. Leaves on Male Rats (Rattus norvegicus) Diabetes Mellitus. Pharmacognosy Journal, 12(5).
  20. Tandi, Joni, Tien Wahyu Handayani, and Agustinus Widodo.(2021). "Qualitative And Quantitative Determination Of Secondary Metabolites And Antidiabetic Potential Of Ocimum Basilicum L. Leaves Extract." RASĀYAN J. Chem, 14(1),PP. 622-628.
  21. Tandi. J, Handayani T. W, Tumanan I. R, Wijaya J. A, Mengkila. M. (2020). The effect of Myrmecodea tuberose Jack ethanol extract on streptozotocin-induced diabetic nephropathy rats. International Journal of Pharmaceutical Research. Sup (1).
  22. Wijaya, H., Novitasari, &; Jubaidah, S. (2018). Comparison of extraction methods against the yield of sea rambui leaf extract (Sonneratia caseolaris L. Engl). Manuntung Scientific Journal, 4(1), 79–83.
  23. Yuliana, I., Asnawati, &; Maria Ulfa. (2021). The Potential of Karamunting Leaves as Phytopharmaceuticals for Diabetes Mellitus Ingredients of Ida Yuliana Asnawati Maria Ulfah.

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