Article Sidebar

Submitted
Jul 16, 2023
Accepted
Nov 1, 2023
Published
Mar 1, 2024
Download
PDF
Statistic
Read Counter : 135 Download : 48

Main Article Content

Abstract

Background: Stress hurts problem-solving abilities, while anxiety disorders and depression are associated with unpleasant feelings and impaired daily functioning. Open field test (OFT) is used to assess anxiety-like behavior in animals by observing their exploratory behavior. Pregnant women are vulnerable to stress, which increases the risk of premature birth and low birth weight. Stress during pregnancy can also lead to preeclampsia and behavioural problems in newborns. Selective serotonin reuptake inhibitors (SSRIs), commonly used antidepressants during pregnancy, help manage mental disorders by increasing serotonin levels and regulating the endocrine system. They reduce glucocorticoid levels, thereby alleviating anxiety and stress in pregnant women. Objectives: This research investigates the correlation between the administration of SSRIs to stress-induced expectant mothers, the manifestation of depression-like behaviour, and the expression of glucocorticoid receptors in the offspring's hippocampus. Material and Methods: This study included four mouse groups: control without stress, control with offspring stress, stress model with footshock on dams and o ffspring, and stress with fluvoxamine treatment. Depressive and stress-related behaviors were measured using OFT. Results: OFT was used to assess the behaviour of offspring mice. Significant differences were observed in the number of crossings in the centre area and behaviour. The SSRI treatment showed potential anxiolytic effects, while stress led to reduced behaviour. These findings contribute to understanding anxiety-related responses and the effects of stress and SSRI treatment in animal models. Conclusions: OFT revealed significant differences in anxiety behaviour, specifically in the number of crossing centres, the centre area, and behaviour. SSRI treatment exhibited anxiolytic effects, while stress-decreased behaviour findings enhanced our understanding of anxiety responses and the impact of stress and SSRI treatment in animal models.

Keywords

Cortisol Anxiety Offspring Maternnal OFT

Article Details

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

How to Cite
Ardianto, C., Aprilia, P., Rahmadi, M., & Sumartha, I. N. B. (2024). Effects of Selective Serotonin Reuptake Inhibitors Exposure in Stressed Pregnant Mice on the Anxiety Behavior of the Offspring: Efek Pemberian SSRIs Prenatal pada Perilaku Kecemasan Offspring dari Model Maternal Stres. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 10(1), 24-39. https://doi.org/10.22487/j24428744.2024.v10.i1.16481

References

  1. Acosta, H., Tuulari, J. J., Scheinin, N. M., Hashempour, N., Rajasilta, O., Lavonius, T. I., et al., (2020). Prenatal maternal depressive symptoms are associated with smaller amygdalar volumes of four-year-old children. Psychiatry Research: Neuroimaging, 304, 1-8.
  2. Alosaimi, F., Boonstra, J. T., Tan, S., Temel, Y., & Jahanshahi, A. (2022). The role of neurotransmitter systems in mediating profound brain stimulation effects in Parkinson's disease. Frontiers in Neuroscience, pp. 16, 1–16.
  3. Anderson, K. N., Lind, J. N., Simeone, R. M., Bobo, W. V., Mitchell, A. A., Riehle-Colarusso, T., et al., (2020). Maternal Use of Specific Antidepressant Medications During Early Pregnancy and the Risk of Selected Birth Defects. JAMA Psychiatry, 77(12), 1246-1255.
  4. Bandelow, B., Michaelis, S., & Wedekind, D. (2017). Treatment of anxiety disorders. Dialogues in Clinical Neuroscience, 19(2), 93-107.
  5. Becker, M., Pinhasov, A., & Ornoy, A. (2021). Animal Models of Depression: What Can They Teach Us about the Human Disease? Diagnostics, 11(1), 1-31.
  6. Bedaso, A., Adams, J., Peng, W., & Sibbritt, D. (2021). Prevalence and determinants of low social support during pregnancy among Australian women: A community-based cross-sectional study. Reproductive Health, 18(158), 1-11.
  7. da Costa, V. F., Ramírez, J. C. C., Ramírez, S. V., Avalo-Zuluaga, J. H., Baptista-de-Souza, D., Canto-de-Souza, L., et al., (2023). Emotional- and cognitive-like responses induced by social defeat stress in male mice are modulated by the BNST, amygdala, and hippocampus. Frontiers in Integrative Neuroscience, 17, 1-17.
  8. Davis, E. P., & Narayan, A. J. (2020). Pregnancy as a period of risk, adaptation, and resilience for mothers and infants. Development and Psychopathology, 32(5), 1625-1639.
  9. Domingues, R. R., Wiltbank, M. C., & Hernandez, L. L. (2023). The antidepressant fluoxetine (Prozac®) modulates estrogen signalling in the uterus and alters oestrous cycles in mice. Molecular and Cellular Endocrinology, 559, 1-8.
  10. Dorofeikova, M., Borkar, C. D., Weissmuller, K., Smith-Osborne, L., Basavanhalli, S., Bean, E., et al., (2023). Effects of footshock stress on social behaviour and neuronal activation in the medial prefrontal cortex and amygdala of male and female mice. PLoS ONE, 18(2), 1-16.
  11. Dreisoerner, A., Junker, N. M., Schlotz, W., Heimrich, J., Bloemeke, S., Ditzen, B., & van Dick, R. (2021). Self-soothing touch and being hugged reduce cortisol responses to stress: A randomised controlled trial on stress, physical touch, and social identity. Comprehensive Psychoneuroendocrinology, 8, 1-10.
  12. Dutton, M., Can, A. T., Lagopoulos, J., & Hermens, D. F. (2022). Stress, mental disorder and ketamine as a novel, rapid acting treatment. European Neuropsychopharmacology, 65, 15–29.
  13. Edinoff, A. N., Akuly, H. A., Hanna, T. A., Ochoa, C. O., Patti, S. J., Ghaffar, Y. A., et al., (2021). Selective Serotonin Reuptake Inhibitors and Adverse Effects: A Narrative Review. Neurology International, 13(3), 387–401.
  14. Eraslan, E., Castelhano-Carlos, M. J., Amorim, L., Soares-Cunha, C., Rodrigues, A. J., & Sousa, N. (2023). Home-cage behavior is impacted by stress exposure in rats. Frontiers in Behavioral Neuroscience, 17, 1-9.
  15. Fukui, N., Watanabe, Y., Motegi, T., Hashijiri, K., Ogawa, M., Egawa, J., et al., (2023). Relationships among autistic traits, depression, anxiety, and maternal-infant bonding in postpartum women. BMC Psychiatry, 23(463), 1-9.
  16. Garakani, A., Murrough, J. W., Freire, R. C., Thom, R. P., Larkin, K., Buono, F. D., & Iosifescu, D. V. (2020). Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options. Frontiers in Psychiatry, pp. 11, 1–21.
  17. Glover, V. (2015). Prenatal stress and its effects on the fetus and the child: Possible underlying biological mechanisms. Advances in Neurobiology, pp. 10, 269–283.
  18. Guo, H., Yang, Y., Qiao, Y., He, J., Yao, W., & Zheng, W. (2021). Heat stress affects fetal brain and intestinal function associated with the alterations of placental barrier in late pregnant mouse. Ecotoxicology and Environmental Safety, pp. 227, 1–11.
  19. Hagberg, K. W., Robijn, A. L., & Jick, S. (2018). Maternal depression and antidepressant use during pregnancy and the risk of autism spectrum disorder in offspring. Clinical Epidemiology, 10, 1599-1612.
  20. Heesbeen, E. J., Bijlsma, E. Y., Verdouw, P. M., van Lissa, C., Hooijmans, C., & Groenink, L. (2023). The effect of SSRIs on fear learning: a systematic review and meta-analysis. *Psychopharmacology, 1-14.
  21. Heinz, D. E., Schöttle, V. A., Nemcova, P., Binder, F. P., Ebert, T., Domschke, D., & Wotjak, C. T. (2021). Exploratory drive, fear, and anxiety are dissociable and independent components in foraging mice. Translational Psychiatry, 11, 1-12.
  22. Hodes, G. E., Kana, V., Menard, C., Merad, M., & Russo, S. J. (2015). Neuroimmune mechanisms of depression. Nature Neuroscience, 18(10), 1386-1393.
  23. Howard, L. M., & Khalifeh, H. (2020). Perinatal mental health: A review of progress and challenges. World Psychiatry, 19(3), 313–327.
  24. Huber, N., Korhonen, S., Hoffmann, D., Leskelä, S., Rostalski, H., Remes, A. M., ... & Haapasalo, A.et al., (2022). Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches. Molecular Psychiatry, 27, 1300–1309.
  25. Jiang, Y., Zou, D., Li, Y., Gu, S., Dong, J., Ma, X., ... & Huang, J. H., et al., (2022). Monoamine Neurotransmitters Control Basic Emotions and Affect Major Depressive Disorders. Pharmaceuticals (Basel), 15(10), 1-19.
  26. Johnson, A., Loh, E., Verbitsky, R., Slessor, J., Franczak, B. C., Schalomon, M., et al., (2023). Examining behavioural test sensitivity and locomotor proxies of anxiety-like behaviour in zebrafish. Scientific Reports, 13, 1–12.
  27. Kageyama, K., Iwasaki, Y., & Daimon, M. (2021). Hypothalamic Regulation of Corticotropin-Releasing Factor under Stress and Stress Resilience. International Journal of Molecular Sciences, 22(22), 1-13.
  28. Kalueff, A. V., Stewart, A. M., Song, C., Berridge, K. C., Graybiel, A. M., & Fentress, J. C. (2016). Neurobiology of rodent self-grooming and its value for translational neuroscience. Nature Reviews Neuroscience, 17(1), 45–59.
  29. Karamihalev, S., Brivio, E., Flachskamm, C., Stoffel, R., Schmidt, M. V., & Chen, A. (2020). Social dominance mediates behavioral adaptation to chronic stress in a sex-specific manner. eLife, 9, 1-17.
  30. Kim, E. J., & Kim, J. J. (2023). Neurocognitive effects of stress: a metaparadigm perspective. Molecular Psychiatry, 1-14.
  31. Klein, C. J. M. I., Budiman, T., Homberg, J. R., Verma, D., Keijer, J., & van Schothorst, E. M. (2022). Measuring locomotor activity and behavioral aspects of rodents living in the home-cage. Frontiers in Behavioral Neuroscience, 16, 1-15.
  32. La-Vu, M., Tobias, B. C., Schuette, P. J., & Adhikari, A. (2020). To Approach or Avoid: An Introductory Overview of the Study of Anxiety Using Rodent Assays. Frontiers in Behavioral Neuroscience, 14(145), 1-7.
  33. León-Rodríguez, A., Fernández-Arjona, M., Grondona, J. M., Pedraza, C., & López-Ávalos, M. D. (2022). Anxiety-like behavior and microglial activation in the amygdala after acute neuroinflammation induced by microbial neuraminidase. Scientific Reports, 12, 1-20.
  34. Lim, K. Y., & Hong, W. (2023). Neural mechanisms of comforting: Prosocial touch and stress buffering. Hormones and Behavior, 153, 1-10.
  35. Lovin, D., & Bernardeau-Moreau, D. (2022). Stress among Students and Difficulty with Time Management: A Study at the University of Galați in Romania. Social Sciences, 11(12), 1-13.
  36. Millard, S. J., Weston-Green, K., & Newell, K. A. (2017). The effects of maternal antidepressant use on offspring behaviour and brain development: Implications for risk of neurodevelopmental disorders. Neuroscience & Biobehavioral Reviews, pp. 80, 743–765.
  37. Mirzaei, M., Yasini Ardekani, S. M., Mirzaei, M., & Dehghani, A. (2019). Prevalence of Depression, Anxiety, and Stress among Adult Population: Results of Yazd Health Study. Iran Journal of Psychiatry, 14(2), 137-146.
  38. Musillo, C., Berry, A., & Cirulli, F. (2022). Prenatal psychological or metabolic stress increases the risk for psychiatric disorders: the "funnel effect" model. Neuroscience and Biobehavioral Reviews, 136, 1-10.
  39. Nitzan, K., David, D., Franko, M., Toledano, R., Fidelman, S., Tenenbaum, Y. S., ... & Doron, R.et al., (2022). Anxiolytic and antidepressants' effect of Crataegus pinnatifida (Shan Zha): biochemical mechanisms. Translational Psychiatry, 12(1), 1-8.
  40. Petković, A., & Chaudhury, D. (2022). Encore: Behavioural animal models of stress, depression, and mood disorders. Frontiers in Behavioral Neuroscience, 16, 1-37.
  41. Schulz, M., da Costa, V., Rötting, A. K., Frohlich, E. K., Claus, R., Grage, L., & Kemper, N. (2023). The Open Field Test as a Tool for Behaviour Analysis in Pigs: Recommendations for Set-Up Standardization - A Systematic Review. European Surgical Research, 64(1), 7-26.
  42. Seibenhener, M.L., & Wooten, M.C. (2015). Use of the Open Field Maze to measure locomotor and anxiety-like behavior in mice. Journal of Visualized Experiments, 96, 1-6.
  43. Sheng, J.A., Bales, N.J., Myers, S.A., Bautista, A.I., Roueinfar, M., Hale, T.M., & Handa, R.J. (2021). The Hypothalamic-Pituitary-Adrenal Axis: Development, Programming Actions of Hormones, and Maternal-Fetal Interactions. Frontiers in Behavioral Neuroscience, 14, 1-21.
  44. Solano, M. E., & Arck, P. C. (2020). Steroids, Pregnancy and Fetal Development. Frontiers in Immunology, 10 (3017), 1-13.
  45. Spurny, B., Vanicek, T., Seiger, R., Reed, M. B., Klöbl, M., Ritter, V., et al., (2021). Effects of SSRI treatment on GABA and glutamate levels in an associative relearning paradigm. NeuroImage, 232, 1-9.
  46. Stafford, L. L., Birnie, M. T., & Conway-Campbell, B. L. (2020). Dynamics of ACTH and Cortisol Secretion and Implications for Disease. Endocrine Reviews, 41(3), 1–21.
  47. Sturman, O., Germain, P. L., & Bohacek, J. (2018). Exploratory rearing: A context- and stress-sensitive behavior recorded in the open-field test. Stress, 21(5), 443-452.
  48. Tseitlin, L., Richmond-Hacham, B., Vita, A., Schreiber, S., Pick, C. G., & Bikovski, L. (2023). Measuring anxiety-like behavior in a mouse model of mTBI: Assessment in standard and home cage assays. Frontiers in Behavioral Neuroscience, 17, 1-9.
  49. Tucker, L. B., Oyola, M. G., Suchecki, D., & Kokras, N. (2022). Editorial: Animal Models of Anxiety and Depression: Exploring the Underlying Mechanisms of Sex Differences. Frontiers in Behavioral Neuroscience, pp. 16, 1–3.
  50. Verbitsky, A., Dopfel, D., & Zhang, N. (2020). Rodent models of post-traumatic stress disorder: Behavioral assessment. Translational Psychiatry, 10, 1-28.
  51. Wahed, W. Y. A., & Safaa, K. H. (2017). Prevalence and associated factors of stress, anxiety, and depression among medical Fayoum University students. Alexandria Journal of Medicine, 53(1), 77-84.
  52. Wang, A. L., Micov, V. B., Kwarteng, F., Wang, R., Hausknecht, K. A., Oubraim, S., et al., (2023). Prenatal ethanol exposure leads to persistent anxiety-like behavior during adulthood, indicated by reduced horizontal and vertical exploratory behaviors. Frontiers in Neuroscience, 17, 1-11.
  53. Wardwell, J., Watanasriyakul, W. T., Normann, M. C., Akinbo, O. I., McNeal, N., Ciosek, S., ... & Grippo, A. J. (2020). Physiological and behavioral responses to observing a sibling experience a direct stressor in prairie voles. Stress, 23(4), 444-456.
  54. Zhang, Y. F., Janke, E., Bhattarai, J. P., Wesson, D. W., & Ma, M. (2022). Self-directed orofacial grooming promotes social attraction in mice via chemosensory communication. iScience, 25(5), 1-15.
  55. Zimcikova, E., Simko, J., Karesova, I., Kremlacek, J., & Malakova, J. (2017). Behavioral effects of antiepileptic drugs in rats: Are the effects on mood and behavior detectable in the open-field test? Seizure, 52, 35-40.

DB Error: Unknown column 'Array' in 'where clause'