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Submitted
Oct 20, 2023
Accepted
Sep 30, 2025
Published
Sep 30, 2025
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Abstract








Background: Eco-enzyme is the result of fermenting organic waste that possesses antibacterial properties. Objectives: This research aims to develop the best formula for an environmentally friendly antiseptic gel. Methods: The analysis carried out in this research includes testing the physical parameters and antibacterial activity of preparation. Results: The liquid eco-enzyme product produced has a distinct strong acid aroma with a pH of 3.1. Antiseptic gels were created in five formulations (F1-F5) by substituting the active alcohol ingredient traditionally used as an antibacterial agent. Test results showed that F1, F2, and F3 met all the requirements for the physical parameters of the gel, including pH (4.5-6.5), viscosity (2000-4000 Cp), spreadability (5-7 cm), and homogeneity (homogeneous). Meanwhile, F4 did not meet the physical parameter of viscosity, and F5 did not meet the parameters for viscosity and spreadability. Antiseptic gel made from eco-enzyme extracted from rambutan fruit peels exhibited higher antibacterial activity against S. aureus and E. coli bacteria compared to two commercial antiseptic gels and F1, which served as the negative control. Conclusion: An antiseptic gel preparation containing rambutan peel eco-enzyme with a concentration of 50% and 50% alcohol (F3) is the best formula.








Keywords

Eco-Enzyme Antibacterial activity Antiseptic gel

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How to Cite
Razak, A. R., Maqnalia, M. M., Lauende, S. H., Ainun, S., & Setiawan, M. R. (2025). Antiseptic Gel Formulation Uses Eco-Enzyme from Rambutan (Nephelium lappaceum) Peels Substitute the Active Ingredient Alcohol : Formulasi Gel Antiseptik Menggunakan Eco-Enzyme Dari Kulit Buah Rambutan (Nephelium lappaceum) Untuk Mensubstitusi Bahan Aktif Alkohol. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 11(1), 57-67. https://doi.org/10.22487/j24428744.2025.v11.i1.16625

References

  1. Angga, L., Prenggono, M. D., dan Budiarti, L. Y. 2015. Identifikasi jenis bakteri kontaminan pada tangan perawat di bangsal penyakit dalam RSUD ULIN Banjarmasin periode Juni-Agustus 2014. Berkala Kedokteran. 11(1): 11–18.
  2. Arista, Y., Kumesan, N., Yamlean, P. V. Y., dan Supriati, H. S. 2013. Formulasi dan uji aktivitas gel antijerawat ekstrak umbi bakung (Crinum Asiaticum L.) terhadap bakteri Staphylococcus aureus secara in vitro. Pharmacon J Ilm Farm–UNSRAT. 2(02): 2302-2493.
  3. Asmawati, dan Setiawan, M. A. 2017. Perbandingan daya hambat antiseptik kewanitaan herbal dan non herbal terhadap jamur Candida albicans. Warta Farmasi. 6(2): 82–89.
  4. Badan Pusat Statistik. 2023. Produksi rambutan di Sulawesi Tengah pada Tahun 2022, BPS, Indonesia.
  5. Larasati, A. L., dan Haribowo, C. 2020. Penggunaan disinfektan dan antiseptik pada pencegahan penularan Covid-19 di masyarakat. Jurnal Farmasetika. 5(3): 137–145.
  6. Marcy, A. D. 2022. Aktivitas Antimikroba Produk Eco-Enzyme dari Sumber Biomassa yang Berbeda. Skripsi. Universitas Tadulako.
  7. Nikam, S. 2017. Anti-acne gel of isotretinoin: formulation and evaluation. Asian J. Pharm. Clin. Res. 10(11): 257-266.
  8. Noviardi, H., Himawan, H. C., dan Anggraeni, R. Formulasi dan aktivitas antibakteri sediaan gel hand sanitizer dari ekstrak etanol biji manga harum manis (Mangifera indica L.) terhadap Escherichia coli dan Staphylococcus aureus. Jurnal Farmamedika. 3(1): 1-10.
  9. Penmatsa, B., Sekhar, D. C., Diwakar, B. S., dan Nagalakshmi, T. V. 2019. Effect of bio-enzyme in the treatment of fresh water bodies. International Journal of Recent Technology and Engineering. 8(1): 308–310.
  10. Ramadhan, I. 2013. Efek Antiseptik Berbagai Merk Hand Sanitizer Terhadap Bakteri Staphylococcus aureus. Skripsi. FKIK Universitas Islam Negri Syarif Hidayatullah.
  11. Sathya Sai International Organization. 2021. Manfaat eco enzyme. URL: https://ssgi.or.id/id/manfaat-eco-enzyme. Diakses tanggal 20 Juni 2023.
  12. Thalib, M. R. S. 2022. Uji Potensi Eco-Enzyme dari Sampah Organik Buah dan Sayur Pasar Tradisional sebagai Desinfektan Alami. Skripsi. Universitas Tadulako.
  13. Win, Y. C. 2011. Ecoenzyme activating the earth’s self-healing power. Alih Bahasa: Gan Chiu Har. Malaysia: Summit Print SDN. BHD. 6(8): 9-14.