Article Sidebar

Submitted
Oct 21, 2023
Accepted
Feb 19, 2024
Published
Oct 1, 2024
Download
PDF
Statistic
Read Counter : 150 Download : 28

Main Article Content

Abstract

Background: Micellar based water (micellar water) is a preparation used to clean the face or makeup with water-based ingredients. Micellar water has moisturizing additives accompanied by antioxidants. Piper crocatum leaves is one of the plants that contain flavonoid compounds so it has the potential as an antioxidant. Micelles are the main component in micellar water preparations derived from amphiphilic block copolymer-type surfactants such as poloxamer. Objectives: The purpose of this study was to formulate, evaluate, and observe the antioxidant activity of the most optimum formulation of micellar based water preparations of Piper crocatum leaves extract with variations in poloxamer 188 concentrations. Material and Methods: The stages of this research were material preparation, extract characteristics evaluation, production of micellar preparations at poloxamer 188 concentrations of 1% (F1); 1.5% (F2); and 2% (F3); preparation characteristics evaluation, stability, particle size, antioxidant activity assay for the optimum formula, and irritation test. Results: The results of the evaluation showed that the pH of the preparation ranged from 4.54 - 4.76; viscosity values ranged from 16.40 - 24.26 cP; particle size ranged from 170.6 – 349.9 nm; and the entire formula did not irritate the skin. Conclusions: Based on the results of this study, it was found that the most optimal concentration of poloxamer 188 was 2% (F3) with IC50 value of 119.63 ppm which categorized as a moderate antioxidant activity.

Keywords

Micellar Water Formulation Poloxamer 188 Piper crocatum Surfactant Antioxidant

Article Details

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

How to Cite
Pratiwi, H., Okzelia, S. D., & Afiah, M. (2024). Formulation of Micellar Based Water from Piper crocatum Leaves Extract Using Various Concentrations of Poloxamer 188: Formulasi Micellar Berbasis Air Ekstrak Daun Sirih Merah (Piper crocatum) dengan Variasi Konsentrasi Poloxamer 188. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 10(2), 214-233. https://doi.org/10.22487/j24428744.2024.v10.i2.16628

References

  1. Abdullah, M., & Maryam, S. (2020). Uji Aktivitas Antioksidan Isolat Fungi Endofit Daun Galing-galing (Cayratia trifolia L.) dengan Metode 1,1-Diphenyl-2-Picrylhydrazil (DPPH). As- Syifaa Jurnal Farmasi , 12(2), 117–122.
  2. Agoes, S. (2019). Tanaman Obat Indonesia Jilid 2. Jakarta: Salemba Medika.
  3. Agustien, G. S., & Susanti. (2021). Pengaruh Jenis Pelarut terhadap Hasil Ekstraksi Daun Lidah Mertua (Sansevieria trifasciata). Seminar Nasional Farmasi , 1(1), 39–45.
  4. Akasia, A. I., Nyoman, D., Putra, N., Nyoman, I., & Putra, G. (2021). Skrining Fitokimia Ekstrak Daun Mangrove Rhizophora mucronata dan Rhizophora apiculata yang dikoleksi dari Kawasan Mangrove Desa Tuban, Bali. JMRT, 4(1), 16–22. https://ojs.unud.ac.id/index.php/JMRT
  5. Akbar, N. D., Nugroho, A. K., & Martono, S. (2021). Formulasi dan Uji Karakteristik SNEDDS Asiklovir. Majalah Farmasetika, 6(5), 375. doi: https://doi.org/10.24198/farmasetika.v6i5.35918
  6. Alfauziah, T. Q. (2018). Mengenal Kosmetik Pembersih Wajah Micellar Water dan Perkembangannya. Majalah Farmasetika , 3(5), 94–97. doi: https://doi.org/10.24198/farmasetika.v3i5.21635
  7. Alfita, R., Ibadillah, A. F., & Laksono, D. T. (2021). Hotplate Magnetic Stirrer Automatic Heat Control and Water Velocity Based on PID (Proportional Integral Derivative). Procedia of Engineering and Life Science, 1(1). doi: https://doi.org/10.21070/pels.v1i1.766
  8. Andini, T., Yusriadi, & Yuliet. (2017). Optimasi Pembentuk Film Polivinil Alkohol dan Humektan Propilen Glikol pada Formula Masker Gel Peel off Sari Buah Labu Kuning (Cucurbita moschata Duchesne) sebagai Antioksidan. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 3(2), 165–173. doi: https://doi.org/10.22487/j24428744.2017.v3.i2.8773
  9. Asim, M., Nazir, M., Chauhdary, Z., Irfan, M., Khalid, S. H., Asghar, S., et al. (2023). Enhanced Solubility and Biological Activity of Dexibuprofen-Loaded Silica-Based Ternary Solid Dispersions. Pharmaceutics, 15(2). doi: https://doi.org/10.3390/pharmaceutics15020399
  10. Aryani, R., Hidayat, A. F., & Karimah, A. Z. (2021). Desain dan Optimasi NLC (Nanostructured Lipid Carriers) Ekstrak Etanol Daun Teh Hijau (Camellia sinensis L. Kuntze) dengan Variasi Lipid. Jurnal Ilmiah Farmasi Farmasyifa, 4(1), 41–48. doi: https://doi.org/10.29313/jiff.v4i1.7151
  11. Azzahra, F., & Budiati, T. (2022). Pengaruh Metode Pengeringan dan Pelarut Ekstraksi Terhadap Rendemen dan Kandungan Kimia Ekstrak Daun Alpukat (Persea americana Mill.). Medical Sains, 7(1), 67–78.
  12. Darmawijaya, I. P., & Astuti, N. P. W. (2021). Uji Sifat Fisik Sediaan Handsanitizer dari Bahan Herbal. Nucleus, 2(1), 18–22. doi: https://doi.org/10.37010/nuc.v2i1.194
  13. Departemen Kesehatan RI. (2008). Farmakope Herbal Indonesia Edisi I. Jakarta: Departemen Kesehatan RI.
  14. Dewi, M. A. P., & Haminuddin, M. (2017). Mutu Fisik Larutan Antinyamuk dan Penerimaan Volunter Minyak Atsiri Biji Mimba (Azadiracta indica. A). Doctoral Dissertation, Akademi Farmasi Putera Indonesia Malang, 1–7. https://repository.poltekkespim.ac.id
  15. Dzakwan, M. (2020). Formulasi Micellar Based Water Ekstrak Bunga Telang. Jurnal Ilmiah Farmasi, 9(2), 61–67. doi: https://doi.org/10.30591/pjif.v%vi%i.2043
  16. Elcistia, R., & Zulkarnain, A. K. (2019). Optimasi Formula Sediaan Krim o/w Kombinasi Oksibenzon dan Titanium Dioksida serta Uji Aktivitas Tabir Surya secara In Vivo. Majalah Farmaseutik, 14(2), 63–78. doi: https://doi.org/10.22146/farmaseutik.v14i2.42596
  17. Fatwami, E. F., & Royani, S. (2023). Skrining Fitokimia dan Uji Antioksidan Ekstrak Daun Cabai Rawit (Capsicum frutescens L.). Journal Syifa Sciences and Clinical Research (JSSCR), 5(2), 253–260. doi: https://doi.org/10.37311/jsscr.v5i2.20896
  18. Febriani, Y., Lubis, S., & Annisa, F. (2022). Formulasi Sediaan Serum Ekstrak Daun Sirih Merah (Piper crocatum Ruiz & Pav.) Sebagai Antioksidan. Journal of Pharmaceutical and Sciences, 5(1), 120–127. https://www.journal-jps.com
  19. Guertler, A., Jontvedt, N. M., Clanner‐Engelshofen, B. M., Cappello, C., Sager, A., & Reinholz, M. (2020). Efficacy and Safety Results of Micellar Water, Cream and Serum for Rosacea in Comparison to a Control Group. Journal of Cosmetic Dermatology, 19(10), 2627–2633. doi: https://doi.org/10.1111/jocd.13591
  20. Handoyo, D. L. Y., & Pranoto, M. E. (2020). Pengaruh Variasi Suhu Pengeringan terhadap Pembuatan Simplisia Daun Mimba (Azadirachta indica). Jurnal Farmasi Tinctura, 1(2), 45–54. doi: https://doi.org/10.35316/tinctura.v1i2.988
  21. Harborne, J. B. (1987). Metode Fitokimia, Penuntun Cara Modern Menganalisa Tumbuhan (Edisi II). Bandung: Penerbit ITB.
  22. Hasanah, N., & Novian, D. R. (2020). Analisis Ekstrak Etanol Buah Labu Kuning (Cucurbita moschata D.). Parapemikir Politeknik Harapan Bersama , 9(1), 54–59. https://ejournal.poltektegal.ac.id/index.php/parape
  23. Kasitowati, R. D., Yamindago, A., & Safitri, M. (2017). Potensi Antioksidan dan Skrining Fitokimia Ekstrak Daun Mangrove Rhizophora mucronata, Pilang Probolinggo. JFMR-Journal of Fisheries and Marine Research, 1(2), 72–77. doi: https://doi.org/10.21776/ub.jfmr.2017.001.02.4
  24. Kawiji, Atmaka W, & Nugraha A A. (2010). Kajian Kadar Kurkuminoid, Total Fenol dan Aktivitas Antioksidan Oleoresin Temulawak (Curcuma xanthorrhiza Roxb) dengan Variasi Teknik Pengeringan dan Warna Kain Penutup. Jurnal Teknologi Hasil Pertanian, 3(2), 102–110.
  25. Kementerian Kesehatan RI. (2017). Farmakope Herbal Indonesia Edisi II. Jakarta: Kementerian Kesehatan RI.
  26. Khoerunisa, I., Najihudin, A., & Hindun, S. (2020). Review Artikel: Solid Lipid Nanoparticles (SLN) Metode dan Karakteristik. Jurnal Insan Farmasi Indonesia, 3(2), 307–316. doi: https://doi.org/10.36387/jifi.v3i2.548
  27. Kosasih, K., Anwar, E., Mudhakir, D., & Supriyono, A. (2022). Improvement of In Vitro Cytotoxic Activity of Cantigi Extract on T47D Breast Cancer cells Using Gelatin Nanoparticles. Original Research Article, 1–11. doi: https://doi.org/10.13140/RG.2.2.25310.92482
  28. Lestari, C. V., & Rohmatulaili. (2022). Analisis Kadar Air dan Sari Kopi Bubuk Menggunakan Metode Gravimetri dan Ekstraksi. Prosiding Seminar Nasional Sains Dan Teknologi Terapan, 5, 337–342.
  29. Lestari, U., Syamsurizal, S., & Handayani, W. T. (2020). Formulasi dan Uji Efektivitas Daya Bersih Sabun Padat Kombinasi Arang Aktif Cangkang Sawit dan Sodium Lauril Sulfat. JPSCR: Journal of Pharmaceutical Science and Clinical Research, 5(2), 136–150. doi: https://doi.org/10.20961/jpscr.v5i2.39869
  30. Maulana, R., & Maesaroh, I. (2022). Formulasi Sediaan Spray Solutio Ekstrak Bawang Putih (Allium sativum L) dan Minyak Serai Wangi (Cymbopogon nardus L) Sebagai Anti Nyamuk dengan Variasi Konsentrasi Propilenglikol. Journal of Herb Farmacological Herba Pharma, 4(2), 104–111. doi: https://doi.org/10.55093/herbapharma.v4i2.341
  31. Menteri Kesehatan RI. (2012). Peraturan Menteri Kesehatan Republik Indonesia Nomor 033 Tahun 2012 Tentang Bahan Tambahan Pangan. Jakarta: Menteri Kesehatan RI.
  32. Milala, A. S. (2022). Sistem Penghantaran Obat dengan Misel Polimer. MEDICINUS, 35(3), 20–31. doi: https://doi.org/10.56951/medicinus.v35i3.104
  33. Molyneux, P. (2004). The Use of the Stable Free Radical Diphenylpicryl-Hydrazyl (DPPH) for Estimating Antioxidant Activity. Songklanakarin J. Sci. Technology, 26(2), 211–219.
  34. Nafisah, U., Sari, Y. D. P., & Latifah, L. N. (2023). Formulasi dan Evaluasi Fisik Sediaan Gel Sampo Minyak Atsiri Bunga Chamomile (Matricaria recucita L.) dengan Variasi Konsentrasi HPMC. Jurnal Ilmiah Farmasi, 3(1), 136–142. doi: http://dx.doi.org/10.30591/pjif.v12i1.4435
  35. Nurdianti, L., Aryani, R., & Indra, I. (2017). Formulasi dan Karakterisasi SNE (Self Nanoemulsion) Astaxanthin dari Haematococcus pluvialis sebagai Super Antioksidan Alami. Jurnal Sains Farmasi & Klinis, 4(1), 30–36. doi: https://doi.org/10.29208/jsfk.2017.4.1.168
  36. Okzelia S.D., & Mardiyyah W. (2023). Formulasi dan Evaluasi Gel Pelembap Ekstrak Mesokarp Semangka [Citrullus lanatus (Thunb.) Matsum. & Nakai] sebagai Antioksidan. Journal of Pharmaceutical and Health Research, 4(1), 30-39. doi: https://doi.org/10.47065/jharma.v4i1.2892
  37. Okzelia, S. D., & Nurdaini, M. (2019). Antioxidant Activity of Pidada (Sonneratia caseolaris (L.) Engl.) Fruit Extract by DPPH Method. Singapore International Multidisciplinary Academic Conference (SIMAC), 1–8. Available from: https://www.researchgate.net/publication/338764485
  38. Oliveira, C. P., Vasconcellos, L. C. G., Ribeiro, M. E. N. P., Ricardo, N. M. P. S., Souza, T. V. de P., Costa, F. de M. L. L., et al. (2011). The Effect of Polymeric Additives on the Solubilisation of a Poorly-Soluble Drug in Micellar Solutions of Pluronic F127. International Journal of Pharmaceutics , 409(1–2), 206–208. doi: https://doi.org/10.1016/j.ijpharm.2011.02.025
  39. Priani, S. E., Abdilla, S. A., & Suparnan, A. (2020). Pengembangan Sediaan Mikroemulsi Gel Antijerawat Mengandung Minyak Kulit Batang Kayu Manis (Cinnamomum burmanni Nees ex BI). Jurnal Ilmiah Farmasi Farmasyifa, 3(1), 9–17. doi: https://doi.org/10.29313/jiff.v3i1.5464
  40. Puspita, P. J., Safithri, M., & Sugiharti, N. P. (2018). Antibacterial Activities of Sirih Merah (Piper crocatum) Leaf Extracts. 5(3), 1–10. http://biokimia.ipb.ac.id.
  41. Reefani, N. K. (2016). Buku Herbal Ajaib Tumpas Penyakit Wanita (Edisi I). Yogyakarta: Kyta.
  42. Ricardo, N. M. P. S., Ricardo, N. M. P. S., Costa, F. de M. L. L., Bezerra, F. W. A., Chaibundit, C., Hermida-Merino, D., et al. (2012). Effect of Water-Soluble Polymers, Polyethylene Glycol and Poly(vinylpyrrolidone), on the Gelation of Aqueous Micellar Solutions of Pluronic Copolymer F127. Journal of Colloid and Interface Science, 368(1), 336–341. doi: https://doi.org/10.1016/j.jcis.2011.10.062
  43. Riwanti, P., Izazih, F., & Amaliyah. (2020). Pengaruh Perbedaan Konsentrasi Etanol pada Kadar Flavonoid Total Ekstrak Etanol 50,70 dan 96% Sargassum polycystum dari Madura. J-PhAM Journal of Pharmaceutical Care Anwar Medika, 82(2), 82–95.
  44. Rompis, F. F., Yamlean, P. V., & Astuty Lolo, W. (2019). Formulasi dan Uji Efektivitas Antioksidan Sediaan Masker Peel-Off Ekstrak Etanol Daun Sesewanua (Cleodendron squamatum Vahl.). Pharmacon, 8(2), 388–396. doi: https://doi.org/10.35799/pha.8.2019.29305
  45. Sanjaya, I. K. N., Giantari, N. K. M., Widyastuti, M. D., & Laksmiani, N. P. L. (2020). Ekstraksi Katekin Dari Biji Alpukat dengan Variasi Pelarut Menggunakan Metode Maserasi. Jurnal Kimia, 14(1), 1–4. doi: https://doi.org/10.24843/jchem.2020.v14.i01.p01
  46. Sari, P. I., Farid, N., Wahyuningsih, S., & Sari, I. (2022). Formulasi dan Uji Efektivitas Spray Antinyamuk Kombinasi Minyak Sereh (Cymbopogon nardus) dan Minyak Nilam (Pogostemon cablin). Jurnal Buana Farma: Jurnal Imiah Farmasi , 2(4), 1–10. https://journal.ubpkarawang.ac.id/mahasiswa/index.php/buanafarma
  47. SNI. (1996). SNI.16-4399-1996 Sediaan Tabir Surya. Jakarta: Dewan Standarisasi Nasional.
  48. Sukmaningrum, K., Yudistira, A., & Antasionasti, I. (2021). Uji Aktivitas Antioksidan Ekstrak Etanol Spons (Stylissa sp.) yang dikoleksi dari Teluk Manado. Pharmacon, 10(1), 756-761. doi: https://doi.org/10.35799/pha.10.2021.32773
  49. Syamsuni. (2006). Farmasetika Dasar dan Hitungan Farmasi. Jakarta: Buku Kedokteran EGC.
  50. Tjitrosoepomo, G. (2005). Taksonomi Tumbuhan Obat-obatan. Yogyakarta: Gadjah Mada University Press.
  51. Untari, E. K., & Robiyanto. (2018). Uji Fisikokimia dan Uji Iritasi Sabun Antiseptik Kulit Daun Aloe vera (L.) Burm. f. Jurnal Jamu Indonesia, 3(2), 55–61. doi: https://doi.org/10.29244/jji.v3i2.54
  52. Vij, A. (2022). Micellar Water: What It Is and How To Use it. Cleveland Clinic. Available online from: https://health.clevelandclinic.org/what-is-micellar-water/. [Accessed November 21, 2022].
  53. Wijaya, A., & Noviana. (2022). Penetapan Kadar Air Simplisia Daun Kemangi (Ocimum basilicum L.) Berdasarkan Perbedaan Metode Pengeringan. Jurnal Riset Kefarmasian Indonesia, 4(2), 185–194. doi: https://doi.org/10.33759/jrki.v4i2.246
  54. Zarwinda, I., Elfariyanti, E., Adriani, A., & Agustina, M. (2022). Formulasi Sediaan Gel Hand Sanitizer dari Ekstrak Etanol Daun Belimbing Wuluh (Averhoa blimbi L.) Kombinasi Gel Lidah Buaya (Aloe vera). Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya, 9(3), 321–330. doi: https://doi.org/10.32539/JKK.V9I3.18939