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Submitted
Aug 5, 2024
Accepted
Jan 18, 2025
Published
Mar 3, 2025
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Abstract

Songga wood (Strychnos ligustrina) from the genus Loganiaceae is a plant that is empirically used as a traditional medicine by people in several regions in Indonesia. This plant is used as a medicine for fever, malaria, antidote, wounds, boils, acne and scabies. This study aims to determine the antioxidant and anti-inflammatory activity of methanol extract of songga wood with Interleukin-8 (IL-8) parameter. Songga wood was macerated with methanol for 3x24 hours until a thick extract was obtained. Antioxidant activity test was conducted by DPPH method and anti-inflammatory by ELISA with IL-8 parameter. Test animals were divided into six groups, namely the normal group, negative control (Na-CMC), positive control (diclofenac sodium) and treatment with three dose variations, namely 50, 100, and 200 mg/KgBB. The results showed that the antioxidant activity value of Songga wood was IC50 84.51 μg/ml.  Furthermore, anti-inflammatory activity showed IL-8 levels at doses of 50 mg/kgBB extract (494.8 pg/ml), 100 mg/kgBB (216.2 pg/ml) and 200 mg/kgBB (118.7 pg/ml). This study concluded that methanol extract of songga wood has strong antioxidant activity and has activity as an anti-inflammatory and the most effective dose of IL-8 levels is 200 mg/kgBB (p>0.05).

Keywords

Songga wood, Strychnos ligustrina, DPPH, Anti-inflammatory, IL-8,

Article Details

How to Cite
Jabbar, A., Wahyuni, W., & Nasrudin, N. (2025). Bioactivity of Songga Wood (Strychnos ligustrina) methanol extract: Antioxidant and Anti-inflammatory against Interleukin-8 (Il-8) levels in Vivo. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 11(1), 13-23. https://doi.org/10.22487/j24428744.2025.v11.i1.17342

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