Article Sidebar
Submitted
Feb 7, 2025
Published
Dec 24, 2025
Download
Statistic
Read Counter : 58
Download : 30
Main Article Content
Abstract
This study evaluates the potential of bioactive compounds from local cardamom (Amomum compactum) as natural drug candidates with antibacterial and antioxidant properties using molecular docking and ADMET analysis. DNA gyrase, a key enzyme in bacterial DNA replication, and NADPH oxidase, a contributor to oxidative stress, were selected as target proteins. Docking results revealed that beta-sesquiphellandrene, 1-piperoylpiperidine, 1,8-cineole, and alpha-terpineol exhibited strong binding affinities. ADMET analysis showed that 1,8-cineole and alpha-terpineol fulfilled bioavailability criteria, making them promising antibacterial and antioxidant drug candidates. These findings suggest further in vitro and in vivo studies for validation.
Article Details
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).