In Silico Evaluation of Cardamom Compounds Against DNA Gyrase and NADPH Oxidase

Authors

  • Ainun Undergraduate Student, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Tadulako University, Jl. Soekarno Hatta Km. 9, Palu, 9418, Indonesia
  • Try Novika Undergraduate Student, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Tadulako University, Jl. Soekarno Hatta Km. 9, Palu, 94148,Indonesia
  • Indriani Indriani Department of Chemistry, Faculty of Mathematics and Natural Sciences, Tadulako University, Jl. Soekarno Hatta Km. 9, Palu, 94148,Indonesia
  • Nov Irmawati Inda Department of Chemistry, Faculty of Mathematics and Natural Sciences, Tadulako University, Jl. Soekarno Hatta Km. 9, Palu, 94148,Indonesia
  • Pasjan Satrimafitrah [Scopus ID: 36697113700], [Orchid ID: 0000-0003-3317-8086], Chemistry Department, Tadulako University

DOI:

https://doi.org/10.22487/25411969.2025.v14.i1.17649

Abstract

This study evaluates the potential of bioactive compounds from local cardamom (Amomum compactum) as natural drug candidates with antibacterial and antioxidant properties using molecular docking and ADMET analysis. DNA gyrase, a key enzyme in bacterial DNA replication, and NADPH oxidase, a contributor to oxidative stress, were selected as target proteins. Docking results revealed that beta-sesquiphellandrene, 1-piperoylpiperidine, 1,8-cineole, and alpha-terpineol exhibited strong binding affinities. ADMET analysis showed that 1,8-cineole and alpha-terpineol fulfilled bioavailability criteria, making them promising antibacterial and antioxidant drug candidates. These findings suggest further in vitro and in vivo studies for validation.

Author Biography

  • Pasjan Satrimafitrah, [Scopus ID: 36697113700], [Orchid ID: 0000-0003-3317-8086], Chemistry Department, Tadulako University

    h-index Scopus: 6

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Published

2025-12-24

Issue

Vol. 14 No. 1 (2025): December Edition

Section

Articles

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