Article Sidebar

Submitted
Jan 27, 2025
Published
Sep 30, 2025
Download
PDF
Statistic
Read Counter : 1 Download : 0

Main Article Content

Abstract








Poorly controlled hypertension in hypertensive patients can increase the risk of cardiovascular disease in the future. Some of the triggering factors are impaired kidney function which is characterized by an increase in creatinine levels and other factors as well, namely an increase in uric acid levels and an increase in blood sugar levels. This study aims to analyze the correlation between blood glucose, creatinine, and uric acid levels in hypertensive patients in Central Sulawesi. With a cross-sectional design, this observational study involved 50 adult hypertensive patients in health facilities. Data were taken from laboratory examination results during visits and analyzed descriptively and analytically. The results showed that 60% of hypertensive patients were female, 62% had a family history of hypertension, and 80% still had blood pressure that was included in the criteria for hypertension. As many as 34% of hypertensive patients had abnormal blood glucose levels, 32% had abnormal creatinine levels, and 26% had abnormal uric acid levels. Still, no relationship was found between the three with blood pressure (p> 0.05). The correlation between blood glucose and blood pressure was -0.221, creatinine and blood pressure was -0.112, and uric acid and blood pressure was 0.132. It can be concluded that there is a positive correlation with a very weak correlation strength between uric acid levels and blood pressure in hypertensive patients.








Keywords

Blood Glucose Creatine Hypertension Uric Acid

Article Details

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

How to Cite
Faustine, I., Yuliet, Y., Hardani, R., Hamdani, S., Alfia, D., Susilawati, N. M., & Adisaputra, A. D. (2025). Correlation of Blood Glucose, Creatinine, and Uric Acid with Blood Pressure in Hypertension Patients : Korelasi Glukosa Darah, Kreatinin, dan Asam Urat dengan Tekanan Darah Pada Pasien Hipertensi. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 11(1), 49-56. https://doi.org/10.22487/j24428744.2025.v11.i1.17638

References

  1. Armiyati, Y. (2010). Hipotensi dan hipertensi intradialisis pada hemodialisis di yogyakarta. November, 1–9.
  2. Azhari, M. H. (M). (2017). Faktor-faktor yang Berhubungan dengan Kejadian Hipertensi di Puskesmas Makrayu Kecamatan Ilir Barat II Palembang. Aisyah: Jurnal Ilmu Kesehatan, 2(1), 195263. https://www.neliti.com/id/publications/195263/
  3. Collard, D., Brouwer, T. F., Peters, R. J. G., Vogt, L., & Van Den Born, B. J. H. (2018). Creatinine rise during blood pressure therapy and the risk of adverse clinical outcomes in patients with type 2 diabetes mellitus a post hoc analysis of the ACCORD-BP randomized controlled trial. Hypertension, 72(6), 1337–1344. https://doi.org/10.1161/HYPERTENSIONAHA.118.11944/SUPPL_FILE/HYP_HYPE201811944_SUPP1.PDF
  4. Dipiro J, talbert R, Yee G, Matzke G, Wells B, P. L. (2017). Pharmacotherapy a pathophysiologyc approach (8th ed.). the MCGraw-Hill education.
  5. Falah, M. (2019). HUBUNGAN JENIS KELAMIN DENGAN ANGKA KEJADIAN HIPERTENSI PADA MASYARAKAT DI KELURAHAN TAMANSARI KOTA TASIKMALAYA. JURNAL MITRA KENCANA KEPERAWATAN DAN KEBIDANAN, 3(1), 85–94. https://doi.org/10.54440/JMK.V3I1.67
  6. Faustine, I., Malik, A., Andrajati, R., & Wanandi, S. I. (2021). Clinical Characteristics and Severity Profile of COVID-19 Patient with Hypertension in Palu, Central Sulawesi. Indonesian Journal of Pharmacy, 32(4), 563–572. https://doi.org/10.22146/ijp.2729
  7. Gerardo González-González, J., Cesar Solis, R., Díaz González-Colmenero, A., Raygoza-Cortez, K., Moreno-Peña, P. J., Sánchez, A. L., McCoy, R. G., Singh Ospina, N., Maraka, S., Brito, J. P., & Rodriguez-Gutierrez, R. (2022). Effect of metformin on microvascular outcomes in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Research and Clinical Practice, 186, 109821. https://doi.org/10.1016/J.DIABRES.2022.109821
  8. Grundy, S. M., Stone, N. J., Bailey, A. L., Beam, C., Birtcher, K. K., Blumenthal, R. S., Braun, L. T., De Ferranti, S., Faiella-Tommasino, J., Forman, D. E., Goldberg, R., Heidenreich, P. A., Hlatky, M. A., Jones, D. W., Lloyd-Jones, D., Lopez-Pajares, N., Ndumele, C. E., Orringer, C. E., Peralta, C. A., … Yeboah, J. (2019). 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. In Circulation (Vol. 139, Issue 25). https://doi.org/10.1161/CIR.0000000000000625
  9. Kementrian Kesehatan RI. (2013). RISET KESEHATAN DASAR.
  10. Luman, A., & Lubis, A. R. (2014). Creatine kinase increases in adults with uncontrolled hypertension. Universa Medicina, 33(1), 36–42. https://doi.org/10.18051/UNIVMED.2014.V33.36-42
  11. Novitasari, A., S., & Tatius, B. (2017). Hiperuresemia Meningkatkan Risiko Hipertensi. Jurnal Kedokteran Muhammadiyah, 5(2). https://jurnal.unimus.ac.id/index.php/kedokteran/article/view/2587
  12. Octviani, P., Rusdi, & Evriyani, D. (2015). Perbandingan Kadar Kreatinin Dan Asam Urat Pada Serum Dan Urin Penderita Hipertensi Dan Normotensi. Bioma, 11(2), 164. https://doi.org/10.21009/bioma11(2).6
  13. Oliveira-Paula, G. H., Pereira, S. C., Tanus-Santos, J. E., & Lacchini, R. (2019).

    Pharmacogenomics And Hypertension: Current Insights

    . Pharmacogenomics and Personalized Medicine, Volume 12, 341–359. https://doi.org/10.2147/PGPM.S230201
  14. Peltzer, K., & Pengpid, S. (2018). The Prevalence and Social Determinants of Hypertension among Adults in Indonesia: A Cross-Sectional Population-Based National Survey. International Journal of Hypertension, 2018. https://doi.org/10.1155/2018/5610725
  15. Persson, S. U., Bsc, D., Sylvi, D., & Persson, U. (2007). Blood pressure reactions to insulin treatment in patients with type 2 diabetes. Int J Angiol, 16.
  16. Petrie, J. R., Guzik, T. J., & Touyz, R. M. (2018). Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms. The Canadian Journal of Cardiology, 34(5), 575. https://doi.org/10.1016/J.CJCA.2017.12.005
  17. Shibata, S., Arima, H., Asayama, K., Hoshide, S., Ichihara, A., & Ishimitsu, T. (2020). Hypertension and related diseases in the era of COVID-19 : a report from the Japanese Society of Hypertension Task Force on COVID-19. Hypertension Research. https://doi.org/10.1038/s41440-020-0515-0
  18. Soetomo. (2015). Ilmu Penyakit Dalam. Pusat Penerbit dan Percetakan Unair.
  19. Sofa, D., Silvana, G., Gita, A. T., Gracia, C., Tsaniyah, H., Rahmasari, V., Maidi, A. P., Utami, M., Nurafifah, A., Pramita Destiani, D., Sinuraya, R. K., & Wicaksono, I. A. (2018). HUBUNGAN TEKANAN DARAH TERHADAP KADAR SERUM KREATININ.
  20. Tim Dinkes Sulawesi Tengah. (2019). Profil Kesehatan Provinsi Sulawesi Tengah Tahun 2019. Dinas Kesehatan Sulawesi Tengah.
  21. Unger, T., Borghi, C., Charchar, F., Khan, N. A., Poulter, N. R., Prabhakaran, D., Ramirez, A., Schlaich, M., Stergiou, G. S., Tomaszewski, M., Wainford, R. D., Williams, B., & Schutte, A. E. (2020). 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension, 75(6), 1334–1357. https://doi.org/10.1161/HYPERTENSIONAHA.120.15026
  22. Zhang, F., Xiang, H., Fan, Y., Ganchuluun, T., Kong, W., Ouyang, Q., Sun, J., Cao, B., Jiang, H., & Nie, S. (2013). The effects of sulfonylureas plus metformin on lipids, blood pressure, and adverse events in type 2 diabetes: a meta-analysis of randomized controlled trials. Endocrine 2013 44:3, 44(3), 648–658. https://doi.org/10.1007/S12020-013-9970-6
  23. Zhou, L., Liu, H., Wen, X., Peng, Y., Tian, Y., & Zhao, L. (2017). Effects of metformin on blood pressure in nondiabetic patients: A meta-analysis of randomized controlled trials. Journal of Hypertension, 35(1), 18–26. https://doi.org/10.1097/HJH.0000000000001119